Epigenetics functions as a bridge between host genetic & environmental factors, aiding in
human health and diseases. Many immune-related diseases, including infectious and …

Background: Smoking-associated DNA methylation levels identified through epigenome-
wide association studies (EWASs) are generally ascribed to smoking-reactive mechanisms …

Background Tobacco smoking is suggested as a risk factor for colorectal cancer (CRC), but
the complex relationship and the potential pathway are not fully understood. Methods We …

This work aims to investigate how smoking exerts effect on the development of inflammatory
bowel disease (IBD). A prospective cohort study and a Mendelian randomization study are …

Due to the fact that the upward trend of several metabolic disorders such as diabetes and
obesity, in individuals especially monozygotic twins, who are under the same effects from …

Smoking exposure during adulthood can disrupt oocyte development in women, contributing
to infertility and possibly adverse birth outcomes. Some of these effects may be reflected in …

Background Advances in upper gastrointestinal endoscopic technology have enabled early
detection and treatment of hypopharyngeal cancer. However, in-depth pharyngeal …

Adipose tissues are broadly distributed in human bodies especially of the obese population,
which have long been considered as a surplus proportion. With the advancement of cell …

Despite extensive research on 5-methylcytosine (5mC) in relation to smoking, there has
been limited exploration into the interaction between smoking and 5-hydroxymethylcytosine …

Background Both genetic and epigenetic variations of GLP1R influence the development
and progression of obesity. However, the underlying mechanism remains elusive. This study …