Phagocytes are key cellular participants determining important aspects of host exposure to
nanomaterials, initiating clearance, biodistribution and the tenuous balance between host …

Mitochondria play essential roles in cellular bioenergetics, biosynthesis, and apoptosis.
During the process of respiration and oxidative phosphorylation, mitochondria utilize oxygen …

Cancer cells exhibit slightly elevated levels of reactive oxygen species (ROS) compared with
normal cells, and approximately 90% of intracellular ROS is produced in mitochondria. In …

The mitochondrion is at the core of cellular energy metabolism, being the site of most ATP
generation. Calcium is a key regulator of mitochondrial function and acts at several levels …

Parkinson's disease is a progressive neurodegenerative disease in the elderly, and no cure
or disease-modifying therapies exist. Several lines of evidence suggest that mitochondrial …

As many diseases have been shown to have several or indirect causes (ie are multifactorial)
the question is what is the relative importance of each factor in a given disease? Also, what …

The increase in human life expectancy has become a challenge to reduce the deleterious
consequences of aging. Nowadays, an increasing number of the population suffer from age …

Nearly 15 types of programmed cell death (PCD) have been identified to date. Among them,
apoptosis is the most common and well-studied type of PCD. In this review, we discuss …

Since the first mitochondrial dysfunction was described in the 1960s, the medicine has
advanced in its understanding the role mitochondria play in health, disease, and aging. A …

Excessive mitochondrial ROS production has been causally linked to the pathophysiology of
aging in the heart and other organs, and plays a deleterious role in several age-related …