This paper is the thirty-ninth consecutive installment of the annual review of research
concerning the endogenous opioid system. It summarizes papers published during 2016 …

BACKGROUND Intravenous ketamine is commonly used for pain management in the
civilian prehospital setting. Several studies have evaluated its effectiveness in the military …

Background Ketamine, a multimodal dissociative anesthetic drug, is widely used as an
analgesic following traumatic injury. Although ketamine may produce anti-inflammatory …

Blast exposure, commonly experienced by military personnel, can cause devastating life-
threatening polysystem trauma. Despite considerable research efforts, the impact of the …

Abstract Background: Tactical Combat Casualty Care (TCCC) guidelines regarding
prehospital analgesia agents have evolved. The guidelines stopped recommending …

Over 230 million people worldwide undergo surgery each year, with this number increasing
annually [1]. More than 80% of surgical patients experience acute postoperative pain …

Background As pediatric patients are typically rare among helicopter emergency medical
systems (HEMS), children might be at risk for oligo-analgesia due to the rescuer's lack of …

Study objective To describe out-of-hospital ketamine use, patient outcomes, and the
potential contribution of ketamine to patient death. Methods We retrospectively evaluated …

Background: Published data on prehospital medical care in combat is limited, likely due to
the chaotic and unpredictable nature of care under fire and difficulty in documentation There …

BACKGROUND Pain control in trauma is an integral part of treatment in combat casualty
care (CCC). More soldiers injured on the battlefield will need analgesics for pain than those …