Since the discovery of the human T-cell leukemia virus-1 (HTLV-1), cellular and animal
models have provided invaluable contributions in the knowledge of viral infection …

Adult T-cell leukemia/lymphoma (ATLL) is an aggressive malignancy of CD4+ T
lymphocytes caused by human T lymphotropic virus type-1 (HTLV-1) infection. HTLV-1 was …

The DDR consists of multiple pathways that sense, signal, and respond to anomalous DNA.
To promote efficient replication, viruses have evolved to engage and even modulate the …

Wnt4 has been shown to promote the recovery of odontogenic differentiation of dental pulp
stem cells under inflammatory conditions, but its role in inflammation and apoptosis of …

The viral transactivator Tax plays a key role in HTLV-1 reactivation and de novo infection.
Previous approaches focused on the histone deacetylase inhibitor (HDACi) Valproate as a …

Human T‐lymphotropic virus type‐1 (HTLV‐1) was the first discovered human oncogenic
retrovirus, the etiological agent of two serious diseases have been identified as adult T‐cell …

Despite human T-cell leukemia virus type 1 (HTLV-1) and HTLV-2 being retroviruses closely
related at a genomic level, HTLV-2 differs from HTLV-1 in terms of pathogenicity in both …

The human T-cell leukemia virus type 1 (HTLV-1)-encoded transactivator and oncoprotein
Tax-1 is essential for HTLV-1 replication. We recently found that Tax-1 interacts with …

Bernhard Fleckenstein, Professor Emeritus and former Chair of the Institute of Clinical and
Molecular Virology at the Friedrich-Alexander-University Erlangen-Nuremberg (FAU) …

In my doctoral thesis, I focused on studying the envelope glycoprotein of ALV (Avian
Leukosis Viruses), a group of retroviruses infecting Galliformes and inducing a variety of …