Aging is accompanied by the decline of organismal functions and a series of prominent
hallmarks, including genetic and epigenetic alterations. These aging-associated epigenetic …

The mammalian target of rapamycin (mTOR) is a protein kinase that controls cellular
metabolism, catabolism, immune responses, autophagy, survival, proliferation, and …

Ageing of the immune system, or immunosenescence, contributes to the morbidity and
mortality of the elderly,. To define the contribution of immune system ageing to organism …

Abstract The coronavirus disease 2019 (COVID-19) pandemic is a global health threat with
particular risk for severe disease and death in older adults and in adults with age-related …

Skeletal muscle contains a designated population of adult stem cells, called satellite cells,
which are generally quiescent. In homeostasis, satellite cells proliferate only sporadically …

Over time, the human DNA methylation landscape accrues substantial damage, which has
been associated with a broad range of age-related diseases, including cardiovascular …

The aged adaptive immune system is characterized by progressive dysfunction as well as
increased autoimmunity. This decline is responsible for elevated susceptibility to infection …

Cellular senescence is a stress response that elicits a permanent cell cycle arrest and
triggers profound phenotypic changes such as the production of a bioactive secretome …

Cells metabolize nutrients for biosynthetic and bioenergetic needs to fuel growth and
proliferation. The uptake of nutrients from the environment and their intracellular metabolism …

Background Dialysis and kidney transplant patients are vulnerable populations for COVID-
19 related disease and mortality. Methods We conducted a prospective study exploring the …