Computational modeling of realistic cell membranes

SJ Marrink, V Corradi, PCT Souza, HI Ingolfsson… - Chemical …, 2019 - ACS Publications
Cell membranes contain a large variety of lipid types and are crowded with proteins,
endowing them with the plasticity needed to fulfill their key roles in cell functioning. The …

Outer membrane vesicles: biogenesis, functions, and issues

R Juodeikis, SR Carding - Microbiology and Molecular Biology …, 2022 - Am Soc Microbiol
This review focuses on nonlytic outer membrane vesicles (OMVs), a subtype of bacterial
extracellular vesicles (BEVs) produced by Gram-negative organisms focusing on the …

Multiscale simulations of biological membranes: the challenge to understand biological phenomena in a living substance

G Enkavi, M Javanainen, W Kulig, T Róg… - Chemical …, 2019 - ACS Publications
Biological membranes are tricky to investigate. They are complex in terms of molecular
composition and structure, functional over a wide range of time scales, and characterized by …

Manipulation and motion of organelles and single molecules in living cells

K Norregaard, R Metzler, CM Ritter… - Chemical …, 2017 - ACS Publications
The biomolecule is among the most important building blocks of biological systems, and a
full understanding of its function forms the scaffold for describing the mechanisms of higher …

Superstatistics and non-Gaussian diffusion

R Metzler - The European Physical Journal Special Topics, 2020 - Springer
Brownian motion and viscoelastic anomalous diffusion in homogeneous environments are
intrinsically Gaussian processes. In a growing number of systems, however, non-Gaussian …

High-speed atomic force microscopy for filming protein molecules in dynamic action

T Ando, S Fukuda, KX Ngo… - Annual Review of …, 2023 - annualreviews.org
Structural biology is currently undergoing a transformation into dynamic structural biology,
which reveals the dynamic structure of proteins during their functional activity to better …

[HTML][HTML] The hierarchical assembly of septins revealed by high-speed AFM

F Jiao, KS Cannon, YC Lin, AS Gladfelter… - Nature …, 2020 - nature.com
Septins are GTP-binding proteins involved in diverse cellular processes including division
and membrane remodeling. Septins form linear, palindromic heteromeric complexes that …

The more the merrier: effects of macromolecular crowding on the structure and dynamics of biological membranes

M Löwe, M Kalacheva, AJ Boersma… - The FEBS …, 2020 - Wiley Online Library
Proteins are essential and abundant components of cellular membranes. Being densely
packed within the limited surface area, proteins fulfil essential tasks for life, which include …

Unexpected crossovers in correlated random-diffusivity processes

W Wang, F Seno, IM Sokolov, AV Chechkin… - New Journal of …, 2020 - iopscience.iop.org
The passive and active motion of micron-sized tracer particles in crowded liquids and inside
living biological cells is ubiquitously characterised by'viscoelastic'anomalous diffusion, in …

Advances in high-speed atomic force microscopy (HS-AFM) reveal dynamics of transmembrane channels and transporters

GR Heath, S Scheuring - Current opinion in structural biology, 2019 - Elsevier
Highlights•HS-AFM detects conformational changes of unlabeled membrane proteins.•In situ
responses to pH, ligands, temperature and light can be visualized.•Developments in …