The regulatory approval of ipilimumab (Yervoy) in 2011 ushered in a new era of cancer
immunotherapies with durable clinical effects. Most of these breakthrough medicines are …

For more than four decades, the cyclic nucleotides cyclic AMP (cAMP) and cyclic GMP
(cGMP) have been recognized as important signaling molecules within cells. Under normal …

Organic nitrates, such as nitroglycerin (GTN), isosorbide-5-mononitrate and isosorbide
dinitrate, and pentaerithrityl tetranitrate (PETN), when given acutely, have potent vasodilator …

Abstract Ethyl 2-((2, 3-bis (nitrooxy) propyl) disulfanyl) benzoate (GT-094) is a novel nitric
oxide (NO) chimera containing an nonsteroidal anti-inflammatory drug (NSAID) and NO …

The possible use of HIV protease inhibitors (HIV‐PI) as new therapeutic option for the
treatment of cancer primarily originated from their success in treating HIV‐related Kaposi's …

The cyclic nucleotides, cAMP and cGMP, are ubiquitous second messengers responsible for
translating extracellular signals to intracellular biological responses in both normal and …

The cellular reaction to external challenges is a tightly regulated process consisting of
integrated processes mediated by a variety of signaling molecules, generated as a result of …

A series of salicylamide derivatives were designed, synthesized and evaluated as
multifunctional agents for the treatment of Alzheimer's disease. In vitro assays demonstrated …

Poor blood− brain barrier penetration of nonsteroidal anti-inflammatory drugs (NSAIDs) has
been blamed for the failure of the selective amyloid lowering agent (SALA) R-flurbiprofen in …

The promising therapeutic potential of the NO-donating hybrid aspirin prodrugs (NO-ASA)
includes induction of chemopreventive mechanisms and has been reported in almost 100 …