While the function of cGAS/STING signalling axis in the innate immune response to DNA
viruses is well deciphered, increasing evidence demonstrates its significant contribution in …

Mitochondria are versatile organelles and essential components of numerous biological
processes such as energy metabolism, signal transduction, and cell fate determination. In …

Bone is one of the most common sites of tumor metastases. During the last step of bone
metastasis, cancer cells colonize and disrupt the bone matrix, which is maintained mainly by …

Chemo‐immunotherapy has shown great success in boosting systemic anti‐tumor effects in
the clinic. However, cancer cells can escape the maximum impact of chemotherapy through …

Pathogenesis exploration and timely intervention of lung injury is quite necessary as it has
harmed human health worldwide for years. Ficolin B (Fcn B) is a recognition molecule that …

Zoonotic poxviruses such as mpox virus (MPXV) continue to threaten public health safety
since the eradication of smallpox. Vaccinia virus (VACV), the prototypic poxvirus used as the …

Defective autophagy is linked to proinflammatory diseases. However, the mechanisms by
which autophagy limits inflammation remain elusive. Here, we found that the pan-FGFR …

The cGMP-AMP Synthase (cGAS)-Stimulator of Interferon Genes (STING) pathway plays a
critical role in sensing dsDNA localized to the cytosol, resulting in the activation of a robust …

Recent studies have expanded the known functions of cGAS–STING in inflammation to a
role in cancer due to its participation in activating immune surveillance. In cancer cells, the …

The DNA sensor cGAS (cyclic GMP-AMP synthase) and its adaptor protein STING
(Stimulator of Interferon Genes) detect the presence of cytosolic DNA as a sign of infection or …