The vertebrate lateral line system comprises a mechanosensory division, with neuromasts
containing hair cells that detect local water movement (“distant touch”); and an …

Abstract CDKN1A/P21 is a potent inhibitor of cell cycle progression and its overexpression is
thought to be associated with inhibition of normal bone regenerative osteogenesis during …

Background Tissue regeneration is widely distributed across the tree of life. Among
vertebrates, salamanders possess an exceptional ability to regenerate amputated limbs and …

The newt, a group of urodele amphibians, has outstanding ability to repeatedly regenerate
various body parts, even in the terrestrial life-stage. In this animal, when the limb is …

Highlights•Some amphibians and sarcopterygians possess giant genomes reaching tens of
gigabases.•Several of these genomes were recently sequenced and found to harbor an …

In some vertebrates, a grave injury to the central nervous system (CNS) results in functional
restoration, rather than in permanent incapacitation. Understanding how these animals …

Background Cardiac regeneration in the adult mouse is not substantial. Some vertebrates,
such as newts and zebrafish, regenerate the heart throughout their lives. To understand how …

Proteins encoded by antigen-processing genes (APGs) provide major histocompatibility
complex (MHC) class I (MHC-I) with antigenic peptides. In mammals, polymorphic multigenic …

Building a blastema from the stump is a key step of salamander limb regeneration. Stump-
derived cells temporarily suspend their identity as they contribute to the blastema by a …

Tissue regeneration requires precise temporal control of cellular processes such as
inflammatory signaling, chromatin remodeling and proliferation. The combination of these …