Plague is a vector-borne disease caused by Yersinia pestis. Transmitted by fleas from
rodent reservoirs, Y. pestis emerged< 6000 years ago from an enteric bacterial ancestor …

Inhalation of the bacterium Yersinia pestis results in primary pneumonic plague. Pneumonic
plague is the most severe manifestation of plague, with mortality rates approaching 100% in …

Yersinia pestis causes human plague and colonizes both a mammalian host and a flea
vector during its transmission cycle. A key barrier to bacterial infection is the host's ability to …

Subverting the host immune response to inhibit inflammation is a key virulence strategy of
Yersinia pestis. The inflammatory cascade is tightly controlled via the sequential action of …

The COVID-19 pandemic caused by the SARS-CoV-2 infection induced lung inflammation
characterized by cytokine storm and fulminant immune response of both resident and …

The innate immune system is the first line of defense against invading pathogens. Innate
immune cells recognize molecular patterns from the pathogen and mount a response to …

The opportunistic Gram-negative bacterium Acinetobacter baumannii (AB) is a leading
cause of life-threatening nosocomial pneumonia. Outbreaks of multidrug resistant (MDR)-AB …

Highlights•Cell surface components mediate resistance of Yersinia to extracellular immune
factors.•Interaction between Yersinia and host cells promotes dissemination and drives …

In a recent study, we demonstrated that vaccination with the polymeric F1 capsule antigen of
the plague pathogen Yersinia pestis led to the rapid induction of a protective humoral …

Biolayer interferometry (BLI) is an optical technique that uses fiber-optic biosensors for label-
free real-time monitoring of protein–protein interactions. In this study, we coupled the …