Short single-stranded nucleic acids are ubiquitous in biological processes; understanding
their physical properties provides insights to nucleic acid folding and dynamics. We used …

The poly (Pro) II (PII) conformation is increasingly recognized as an important element in
peptide and protein conformation. Circular dichroism (CD) is one of the most useful methods …

The alanine-based peptide Ac-XX (A) 7OO-NH2, referred to as XAO (where X, A, and O
denote diaminobutyric acid, alanine, and ornithine, respectively), has recently been …

A reliable intrinsic propensity scale of amino acid residues is indispensable for an
assessment of how local conformational distributions in the unfolded state can affect the …

Förster Resonance Energy Transfer (FRET) experiments probe molecular distances via
distance dependent energy transfer from an excited donor dye to an acceptor dye. Single …

The tumor suppressor p53 is a member of the emerging class of proteins that have both
folded and intrinsically disordered domains, which are a challenge to structural biology. Its N …

Background Secondary structures are elements of great importance in structural biology,
biochemistry and bioinformatics. They are broadly composed of two repetitive structures …

An emerging class of disordered proteins underlies the elasticity of many biological tissues.
Elastomeric proteins are essential to the function of biological machinery as diverse as the …

Nucleic acids are polyanionic molecules that were historically considered to be solely
surrounded by a shell of water molecules and a neutralizing cloud of monovalent and …

We present a coarse residue-based computational method to rapidly compute the solution
scattering profile from a protein with dynamical fluctuations. The method is built upon a …