Cellular senescence in asthma: from pathogenesis to therapeutic challenges
R Wan, P Srikaram, V Guntupalli, C Hu, Q Chen… - …, 2023 - thelancet.com
Asthma is a heterogeneous chronic respiratory disease that impacts nearly 10% of the
population worldwide. While cellular senescence is a normal physiological process, the …
population worldwide. While cellular senescence is a normal physiological process, the …
[HTML][HTML] Exploring cellular senescence in the musculoskeletal system: any insights for biomarkers discovery?
L Gerosa, AM Malvandi, M Malavolta… - Ageing research …, 2023 - Elsevier
The locomotor system comprises skeletal muscles and bones with active metabolism and
cellular turnover. Chronic locomotor system disorders gradually arising with aging are …
cellular turnover. Chronic locomotor system disorders gradually arising with aging are …
Discovery of senolytics using machine learning
V Smer-Barreto, A Quintanilla, RJR Elliott… - Nature …, 2023 - nature.com
Cellular senescence is a stress response involved in ageing and diverse disease processes
including cancer, type-2 diabetes, osteoarthritis and viral infection. Despite growing interest …
including cancer, type-2 diabetes, osteoarthritis and viral infection. Despite growing interest …
Mitochondria-targeted senotherapeutic interventions
Healthy aging is the art of balancing a delicate scale. On one side of the scale, there are the
factors that make life difficult with aging, and on the other side are the products of human …
factors that make life difficult with aging, and on the other side are the products of human …
Rutin is a potent senomorphic agent to target senescent cells and can improve chemotherapeutic efficacy
H Liu, Q Xu, H Wufuer, Z Li, R Sun, Z Jiang, X Dou… - Aging …, 2024 - Wiley Online Library
Aging is a major risk factor for most chronic disorders, for which cellular senescence is one
of the central hallmarks. Senescent cells develop the pro‐inflammatory senescence …
of the central hallmarks. Senescent cells develop the pro‐inflammatory senescence …
The impact of cellular senescence in human adipose tissue
A Nerstedt, U Smith - Journal of Cell Communication and Signaling, 2023 - Springer
In the last decades the prevalence of obesity has increased dramatically, and the worldwide
epidemic of obesity and related metabolic diseases has contributed to an increased interest …
epidemic of obesity and related metabolic diseases has contributed to an increased interest …
Inflammation, oxidative stress, senescence in atherosclerosis: thioredoxine-1 as an emerging therapeutic target
K El Hadri, R Smith, E Duplus, C El Amri - International journal of …, 2021 - mdpi.com
Atherosclerosis is a leading cause of cardiovascular diseases (CVD) worldwide and
intimately linked to aging. This pathology is characterized by chronic inflammation, oxidative …
intimately linked to aging. This pathology is characterized by chronic inflammation, oxidative …
Antiaging agents: Safe interventions to slow aging and healthy life span extension
JK Liu - Natural products and bioprospecting, 2022 - Springer
Human longevity has increased dramatically during the past century. More than 20% of the 9
billion population of the world will exceed the age of 60 in 2050. Since the last three …
billion population of the world will exceed the age of 60 in 2050. Since the last three …
The role of vitamin D on redox regulation and cellular senescence
E Sosa-Díaz, EY Hernández-Cruz… - Free Radical Biology …, 2022 - Elsevier
Vitamin D is considered an essential micronutrient for human health that is metabolized into
a multifunctional secosteroid hormone. We can synthesize it in the skin through ultraviolet B …
a multifunctional secosteroid hormone. We can synthesize it in the skin through ultraviolet B …
[HTML][HTML] Senolytics: eliminating senescent cells and alleviating intervertebral disc degeneration
Y Wu, S Shen, Y Shi, N Tian, Y Zhou… - … in bioengineering and …, 2022 - frontiersin.org
Intervertebral disc degeneration (IVDD) is the main cause of cervical and lumbar
spondylosis. Over the past few years, the relevance between cellular senescence and IVDD …
spondylosis. Over the past few years, the relevance between cellular senescence and IVDD …