Cellular senescence in asthma: from pathogenesis to therapeutic challenges

R Wan, P Srikaram, V Guntupalli, C Hu, Q Chen… - …, 2023 - thelancet.com
Asthma is a heterogeneous chronic respiratory disease that impacts nearly 10% of the
population worldwide. While cellular senescence is a normal physiological process, the …

[HTML][HTML] Exploring cellular senescence in the musculoskeletal system: any insights for biomarkers discovery?

L Gerosa, AM Malvandi, M Malavolta… - Ageing research …, 2023 - Elsevier
The locomotor system comprises skeletal muscles and bones with active metabolism and
cellular turnover. Chronic locomotor system disorders gradually arising with aging are …

Discovery of senolytics using machine learning

V Smer-Barreto, A Quintanilla, RJR Elliott… - Nature …, 2023 - nature.com
Cellular senescence is a stress response involved in ageing and diverse disease processes
including cancer, type-2 diabetes, osteoarthritis and viral infection. Despite growing interest …

Mitochondria-targeted senotherapeutic interventions

MC Atayik, U Çakatay - Biogerontology, 2022 - Springer
Healthy aging is the art of balancing a delicate scale. On one side of the scale, there are the
factors that make life difficult with aging, and on the other side are the products of human …

Rutin is a potent senomorphic agent to target senescent cells and can improve chemotherapeutic efficacy

H Liu, Q Xu, H Wufuer, Z Li, R Sun, Z Jiang, X Dou… - Aging …, 2024 - Wiley Online Library
Aging is a major risk factor for most chronic disorders, for which cellular senescence is one
of the central hallmarks. Senescent cells develop the pro‐inflammatory senescence …

The impact of cellular senescence in human adipose tissue

A Nerstedt, U Smith - Journal of Cell Communication and Signaling, 2023 - Springer
In the last decades the prevalence of obesity has increased dramatically, and the worldwide
epidemic of obesity and related metabolic diseases has contributed to an increased interest …

Inflammation, oxidative stress, senescence in atherosclerosis: thioredoxine-1 as an emerging therapeutic target

K El Hadri, R Smith, E Duplus, C El Amri - International journal of …, 2021 - mdpi.com
Atherosclerosis is a leading cause of cardiovascular diseases (CVD) worldwide and
intimately linked to aging. This pathology is characterized by chronic inflammation, oxidative …

Antiaging agents: Safe interventions to slow aging and healthy life span extension

JK Liu - Natural products and bioprospecting, 2022 - Springer
Human longevity has increased dramatically during the past century. More than 20% of the 9
billion population of the world will exceed the age of 60 in 2050. Since the last three …

The role of vitamin D on redox regulation and cellular senescence

E Sosa-Díaz, EY Hernández-Cruz… - Free Radical Biology …, 2022 - Elsevier
Vitamin D is considered an essential micronutrient for human health that is metabolized into
a multifunctional secosteroid hormone. We can synthesize it in the skin through ultraviolet B …

[HTML][HTML] Senolytics: eliminating senescent cells and alleviating intervertebral disc degeneration

Y Wu, S Shen, Y Shi, N Tian, Y Zhou… - … in bioengineering and …, 2022 - frontiersin.org
Intervertebral disc degeneration (IVDD) is the main cause of cervical and lumbar
spondylosis. Over the past few years, the relevance between cellular senescence and IVDD …