The amide functional group plays a key role in the composition of biomolecules, including
many clinically approved drugs. Bioisosterism is widely employed in the rational …

Abstract N-acylethanolamines (NAEs), including N-palmitoylethanolamine (PEA), N-
oleoylethanolamine (OEA), N-arachidonoylethanolamine (AEA, anandamide), N …

Recently, nutraceutical bioactive compounds in foods have been discovered for their
potential health benefits regarding the prevention of chronic disorders, such as cancer, and …

Cannabis has been used for medicinal purposes for thousands of years. The prohibition of
cannabis in the middle of the 20th century has arrested cannabis research. In recent years …

Drugs selectively targeting CB2 hold promise for treating neurodegenerative disorders,
inflammation, and pain while avoiding psychotropic side effects mediated by CB1. The …

Forest trees are a major source of biogenic volatile organic compounds (BVOCs). Terpenes
and terpenoids are known as the main BVOCs of forest aerosols. These compounds have …

The CB 1 and CB 2 cannabinoid receptors (CB 1 R, CB 2 R) are members of the G protein-
coupled receptor (GPCR) family that were identified over 20 years ago. CB 1 Rs and CB 2 …

Cannabidiol (CBD) is a non-psychotropic phytocannabinoid of the plant Cannabis sativa L.
CBD is increasingly being explored as an alternative to conventional therapies to treat …

Exposure to stress is an undeniable, but in most cases surmountable, part of life. However,
in certain individuals, exposure to severe or cumulative stressors can lead to an array of …

Current pain therapeutics offer inadequate relief to patients with chronic pain. A growing
literature supports that pro-inflammatory cytokine signaling between immune, glial, and …