Once thought to be a waste product of anaerobic metabolism, lactate is now known to form
continuously under aerobic conditions. Shuttling between producer and consumer cells …

After a century, it's time to turn the page on understanding of lactate metabolism and
appreciate that lactate shuttling is an important component of intermediary metabolism in …

We evaluated the hypothesis that lactate shuttling helps support the nutritive needs of
injured brains. To that end, we utilized dual isotope tracer [6, 6-2H2] glucose, that is, D2 …

Since its discovery in 1780, lactate has long been misunderstood as a waste by-product of
anaerobic glycolysis with multiple deleterious effects. Owing to the lactate shuttle concept …

Mammalian organs convert dietary nutrients into circulating metabolites and share them to
maintain whole-body metabolic homeostasis. While the concentrations of circulating …

Because it is the product of glycolysis and main substrate for mitochondrial respiration,
lactate is the central metabolic intermediate in cerebral energy substrate delivery. Our recent …

Idiopathic pulmonary fibrosis (IPF) is a chronic and progressive lung disease characterized
by excessive deposition of fibrotic connective tissue in the lungs. Emerging evidence …

Once thought to be a waste product of oxygen limited (anaerobic) metabolism, lactate is now
known to form continuously under fully oxygenated (aerobic) conditions. Lactate shuttling …

Because of the many energy-demanding functions they perform and their physical location
in the lung, alveolar epithelial type II (ATII) cells have a rapid cellular metabolism and the …

The discovery of the lactate shuttle (LS) mechanism may have two opposite perceptions, It
may mean very little, because the body normally and inexorably uses the LS mechanism. On …