Metallo-β-lactamases in the age of multidrug resistance: from structure and mechanism to evolution, dissemination, and inhibitor design
G Bahr, LJ Gonzalez, AJ Vila - Chemical Reviews, 2021 - ACS Publications
Antimicrobial resistance is one of the major problems in current practical medicine. The
spread of genes coding for resistance determinants among bacteria challenges the use of …
spread of genes coding for resistance determinants among bacteria challenges the use of …
[HTML][HTML] β-Lactamases and β-Lactamase Inhibitors in the 21st Century
The β-lactams retain a central place in the antibacterial armamentarium. In Gram-negative
bacteria, β-lactamase enzymes that hydrolyze the amide bond of the four-membered β …
bacteria, β-lactamase enzymes that hydrolyze the amide bond of the four-membered β …
Past and present perspectives on β-lactamases
K Bush - Antimicrobial agents and chemotherapy, 2018 - Am Soc Microbiol
ABSTRACT β-Lactamases, the major resistance determinant for β-lactam antibiotics in Gram-
negative bacteria, are ancient enzymes whose origins can be traced back millions of years …
negative bacteria, are ancient enzymes whose origins can be traced back millions of years …
[HTML][HTML] Carbapenem-Resistant Klebsiella pneumoniae: Virulence Factors, Molecular Epidemiology and Latest Updates in Treatment Options
T Karampatakis, K Tsergouli, P Behzadi - Antibiotics, 2023 - mdpi.com
Klebsiella pneumoniae is a Gram-negative opportunistic pathogen responsible for a variety
of community and hospital infections. Infections caused by carbapenem-resistant K …
of community and hospital infections. Infections caused by carbapenem-resistant K …
Klebsiella oxytoca complex: update on taxonomy, antimicrobial resistance, and virulence
J Yang, H Long, Y Hu, Y Feng… - Clinical microbiology …, 2022 - Am Soc Microbiol
Klebsiella oxytoca is actually a complex of nine species—Klebsiella grimontii, Klebsiella
huaxiensis, Klebsiella michiganensis, K. oxytoca, Klebsiella pasteurii, Klebsiella …
huaxiensis, Klebsiella michiganensis, K. oxytoca, Klebsiella pasteurii, Klebsiella …
[HTML][HTML] Rapid evolution and host immunity drive the rise and fall of carbapenem resistance during an acute Pseudomonas aeruginosa infection
R Wheatley, J Diaz Caballero, N Kapel… - Nature …, 2021 - nature.com
It is well established that antibiotic treatment selects for resistance, but the dynamics of this
process during infections are poorly understood. Here we map the responses of …
process during infections are poorly understood. Here we map the responses of …
[HTML][HTML] Molecular Epidemiology of Carbapenemases in Enterobacteriales from Humans, Animals, Food and the Environment
G Taggar, M Attiq Rheman, P Boerlin, MS Diarra - Antibiotics, 2020 - mdpi.com
The Enterobacteriales order consists of seven families including Enterobacteriaceae,
Erwiniaceae, Pectobacteriaceae, Yersiniaceae, Hafniaceae, Morganellaceae, and …
Erwiniaceae, Pectobacteriaceae, Yersiniaceae, Hafniaceae, Morganellaceae, and …
[HTML][HTML] Laboratory detection and clinical implication of oxacillinase-48 like carbapenemase: the hidden threat
YD Bakthavatchalam, S Anandan… - Journal of global …, 2016 - journals.lww.com
Carbapenemase producing Gram-negative pathogen is of great concern for physician. The
challenging aspects are treatment option and infection control. Monitoring of respective …
challenging aspects are treatment option and infection control. Monitoring of respective …
Carbapenemases in Enterobacteriaceae: types and molecular epidemiology
L Martínez-Martínez, JJ González-López - Enfermedades infecciosas y …, 2014 - Elsevier
El mecanismo más importante de resistencia a carbapenémicos en enterobacterias es la
producción de carbapenemasas, aunque dicha resistencia también puede deberse a la …
producción de carbapenemasas, aunque dicha resistencia también puede deberse a la …
Metagenomic analysis reveals that bacteriophages are reservoirs of antibiotic resistance genes
J Subirats, A Sànchez-Melsió, CM Borrego… - International journal of …, 2016 - Elsevier
A metagenomics approach was applied to explore the presence of antibiotic resistance
genes (ARGs) in bacteriophages from hospital wastewater. Metagenomic analysis showed …
genes (ARGs) in bacteriophages from hospital wastewater. Metagenomic analysis showed …