[HTML][HTML] Effects of terpenes in the treatment of visceral leishmaniasis: A systematic review of preclinical evidence

VD Raimundo, RPR Carvalho… - Pharmacological …, 2022 - Elsevier
Visceral leishmaniasis (VL) is a severe and potentially fatal neglected tropical disease,
being considered a public health concern in many countries worldwide. There are still no …

Road‐map of pre‐clinical treatment for Visceral Leishmaniasis

P Mazire, V Agarwal, A Roy - Drug Development Research, 2022 - Wiley Online Library
Visceral leishmaniasis (VL) or Kala‐azar, is the most lethal form of leishmaniasis, is still
prevalent in many countries where it is endemic. It is a threat to human life caused by …

Impact of visceral leishmaniasis on local organ metabolism in hamsters

M Lesani, C Gosmanov, A Paun, MD Lewis, LI McCall - Metabolites, 2022 - mdpi.com
Leishmania is an intracellular parasite with different species pathogenic to humans and
causing the disease leishmaniasis. Leishmania donovani causes visceral leishmaniasis …

Protective efficacy in a Hamster model of a multivalent vaccine for human visceral Leishmaniasis (MuLeVaClin) consisting of the KMP11, LEISH-F3+, and LJL143 …

L Fernández, JC Solana, C Sánchez, MÁ Jiménez… - Microorganisms, 2021 - mdpi.com
Visceral leishmaniasis (VL) is the most severe clinical form of leishmaniasis, fatal if
untreated. Vaccination is the most cost-effective approach to disease control; however, to …

Status of IL‐4 and IL‐10 driven markers in experimental models of Visceral Leishmaniasis

S Moulik, J Karmakar, S Joshi, A Dube… - Parasite …, 2021 - Wiley Online Library
Aim Leishmania donovani, the causative agent for visceral leishmaniasis (VL), modulates
host monocytes/macrophages to ensure its survival. However, knowledge regarding the host …

Bioluminescent Imaging Identifies Thymus, As Overlooked Colonized Organ, in a Chronic Model of Leishmania donovani Mouse Visceral Leishmaniasis

B Dominguez-Asenjo, C Gutierrez-Corbo… - ACS Infectious …, 2021 - ACS Publications
The search for new drugs against neglected parasitic diseases has experienced a major
boost in recent years with the incorporation of bioimaging techniques. Visceral …

Assay development in leishmaniasis drug discovery: a comprehensive review

B Zulfiqar, VM Avery - Expert Opinion on Drug Discovery, 2022 - Taylor & Francis
Introduction Cutaneous, muco-cutaneous and visceral leishmaniasis occur due to an
infection with the protozoan parasite Leishmania. The current therapeutic options are limited …

[HTML][HTML] Evolving immunometabolic response to the early Leishmania infantum infection in the spleen of BALB/c mice described by gene expression profiling

G Palacios, R Diaz-Solano, B Valladares… - Acta Tropica, 2023 - Elsevier
Transcriptional analysis is a useful approximation towards the identification of global
changes in host-pathogen interaction, in order to elucidate tissue-specific immune …

Quantitative monitoring of experimental and human leishmaniasis employing amastigote-specific genes

M Roy, D Sarkar, M Chatterjee - Parasitology, 2022 - cambridge.org
The gold standard for diagnosis of leishmaniasis is the microscopic detection of
amastigotes/Leishman Donovan (LD) bodies, but its moderate sensitivity necessitates the …

Immunoprophylaxis using polypeptide chimera vaccines plus adjuvant system promote Th1 response controlling the spleen parasitism in hamster model of visceral …

MR Gusmão, TLVDP Ostolin, LM Carvalho, AFP Costa… - Vaccine, 2022 - Elsevier
In recent years, several advances have been observed in vaccinology especially for
neglected tropical diseases (NTDs). One of the tools employed is epitope prediction by …