The 2022 report on the human proteome from the HUPO human proteome project
The 2022 Metrics of the Human Proteome from the HUPO Human Proteome Project (HPP)
show that protein expression has now been credibly detected (neXtProt PE1 level) for 18 …
show that protein expression has now been credibly detected (neXtProt PE1 level) for 18 …
The complexity of kidney disease and diagnosing it–cystatin C, selective glomerular hypofiltration syndromes and proteome regulation
L Malmgren, C Öberg, E den Bakker… - Journal of internal …, 2023 - Wiley Online Library
Estimation of kidney function is often part of daily clinical practice, mostly done by using the
endogenous glomerular filtration rate (GFR)‐markers creatinine or cystatin C. A …
endogenous glomerular filtration rate (GFR)‐markers creatinine or cystatin C. A …
Trans-proteomic pipeline: robust mass spectrometry-based proteomics data analysis suite
The Trans-Proteomic Pipeline (TPP) mass spectrometry data analysis suite has been in
continual development and refinement since its first tools, PeptideProphet and …
continual development and refinement since its first tools, PeptideProphet and …
Proteomics of human biological fluids for biomarker discoveries: technical advances and recent applications
L Dayon, O Cominetti, M Affolter - Expert review of proteomics, 2022 - Taylor & Francis
Introduction Biological fluids are routine samples for diagnostic testing and monitoring.
Blood samples are typically measured because of their moderate invasive collection and …
Blood samples are typically measured because of their moderate invasive collection and …
[HTML][HTML] Evaluation of circulating plasma proteins in breast cancer using Mendelian randomisation
A Mälarstig, F Grassmann, L Dahl, M Dimitriou… - Nature …, 2023 - nature.com
Biomarkers for early detection of breast cancer may complement population screening
approaches to enable earlier and more precise treatment. The blood proteome is an …
approaches to enable earlier and more precise treatment. The blood proteome is an …
[HTML][HTML] Comprehensive proteomics and meta-analysis of COVID-19 host response
H Babačić, W Christ, JE Araújo, G Mermelekas… - Nature …, 2023 - nature.com
COVID-19 is characterised by systemic immunological perturbations in the human body,
which can lead to multi-organ damage. Many of these processes are considered to be …
which can lead to multi-organ damage. Many of these processes are considered to be …
Progress identifying and analyzing the human proteome: 2021 metrics from the HUPO human proteome project
The 2021 Metrics of the HUPO Human Proteome Project (HPP) show that protein expression
has now been credibly detected (neXtProt PE1 level) for 18 357 (92.8%) of the 19 778 …
has now been credibly detected (neXtProt PE1 level) for 18 357 (92.8%) of the 19 778 …
[HTML][HTML] Metastatic phenotype and immunosuppressive tumour microenvironment in pancreatic ductal adenocarcinoma: Key role of the urokinase plasminogen …
Background Previous studies have revealed the role of dysregulated urokinase
plasminogen activator (encoded by PLAU) expression and activity in several pathways …
plasminogen activator (encoded by PLAU) expression and activity in several pathways …
Instrumentation at the leading edge of proteomics
The proteome, or collection of proteoforms expressed in a biological system, is dynamic and
heterogeneous. As our appreciation for the complexity of the proteome has evolved, so have …
heterogeneous. As our appreciation for the complexity of the proteome has evolved, so have …
Clinical applications of plasma proteomics and peptidomics: Towards precision medicine
In the context of precision medicine, disease treatment requires individualized strategies
based on the underlying molecular characteristics to overcome therapeutic challenges …
based on the underlying molecular characteristics to overcome therapeutic challenges …