Drug hypersensitivity reactions are a serious concern in clinical practice because they can
be severe and result in lifelong sequelae. An accurate diagnosis and identification of the …

Drug hypersensitivity reactions (DHRs) are type B adverse drug reactions (ADRs)
traditionally defined as unpredictable, dose independent and not related to the drug …

Background Evidence is lacking on the association between antibiotic use and risk of
Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) in Asians. Objective …

Stevens‒Johnson syndrome and toxic epidermal necrolysis (SJS/TEN) are severe
cutaneous adverse drug reactions characterized by widespread keratinocyte cell death and …

Background: Chemical allergies are T cell-mediated diseases that often manifest in the skin
as allergic contact dermatitis (ACD). To prevent ACD on a public health scale and avoid …

Background Flucloxacillin (FLX)-induced liver injury is immune-mediated and highly
associated to HLA-B∗ 57: 01 expression. Host factors leading to drug-induced liver injury …

Pharmacogenomics aims to understand how genetic variation influences drug response.
This understanding has the potential to support clinicians to deliver personalized therapy …

HLA-I transgenic mouse models are now available to study ABC, FLX and carbamazepine-
induced adverse reactions. In vivo studies range from characterizing drug-antigen …

Measure of drug-mediated immune reactions that are dependent on the patient's genotype
determine individual medication protocols. Despite extensive clinical trials prior to the …

Allergic diseases are a heterogeneous group of disorders resulting from exaggerated type 2
inflammation. Although typically viewed as polygenic multifactorial disorders caused by the …