RNAi-based therapeutics and novel RNA bioengineering technologies
RNA interference (RNAi) provides researchers with a versatile means to modulate target
gene expression. The major forms of RNAi molecules, genome-derived microRNAs …
gene expression. The major forms of RNAi molecules, genome-derived microRNAs …
microRNAs biogenesis, functions and role in tumor angiogenesis
T Annese, R Tamma, M De Giorgis, D Ribatti - Frontiers in oncology, 2020 - frontiersin.org
microRNAs (miRNAs) are small non-coding RNA molecules, evolutionary conserved. They
target more than one mRNAs, thus influencing multiple molecular pathways, but also …
target more than one mRNAs, thus influencing multiple molecular pathways, but also …
The non-canonical aspects of microRNAs: many roads to gene regulation
CJ Stavast, SJ Erkeland - Cells, 2019 - mdpi.com
MicroRNAs (miRNAs) are critical regulators of gene expression. As miRNAs are frequently
deregulated in many human diseases, including cancer and immunological disorders, it is …
deregulated in many human diseases, including cancer and immunological disorders, it is …
Action mechanisms and research methods of tRNA-derived small RNAs
Y Xie, L Yao, X Yu, Y Ruan, Z Li, J Guo - Signal transduction and …, 2020 - nature.com
Abstract tRNA-derived small RNAs (tsRNAs), including tRNA-derived fragments (tRFs) and
tRNA halves (tiRNAs), are small regulatory RNAs processed from mature tRNAs or …
tRNA halves (tiRNAs), are small regulatory RNAs processed from mature tRNAs or …
Regulation and function of RNA pseudouridylation in human cells
EK Borchardt, NM Martinez… - Annual review of …, 2020 - annualreviews.org
Recent advances in pseudouridine detection reveal a complex pseudouridine landscape
that includes messenger RNA and diverse classes of noncoding RNA in human cells. The …
that includes messenger RNA and diverse classes of noncoding RNA in human cells. The …
[HTML][HTML] tRNA-derived fragments: Mechanisms underlying their regulation of gene expression and potential applications as therapeutic targets in cancers and virus …
X Yu, Y Xie, S Zhang, X Song, B Xiao, Z Yan - Theranostics, 2021 - ncbi.nlm.nih.gov
Abstract tRNA-derived fragments (tRFs) are a new category of regulatory noncoding RNAs
with distinct biological functions in cancers and stress-induced diseases. Herein, we first …
with distinct biological functions in cancers and stress-induced diseases. Herein, we first …
Deciphering the tRNA-derived small RNAs: origin, development, and future
Transfer RNA (tRNA)-derived small RNAs (tsRNAs), a novel category of small noncoding
RNAs, are enzymatically cleaved from tRNAs. Previous reports have shed some light on the …
RNAs, are enzymatically cleaved from tRNAs. Previous reports have shed some light on the …
Transfer RNA-derived fragments and tRNA halves: biogenesis, biological functions and their roles in diseases
Y Shen, X Yu, L Zhu, T Li, Z Yan, J Guo - Journal of Molecular Medicine, 2018 - Springer
The number of studies on non-coding RNAs has increased substantially in recent years
owing to their importance in gene regulation. However, the biological functions of small …
owing to their importance in gene regulation. However, the biological functions of small …
tRNA-derived fragments and tRNA halves: the new players in cancers
L Zhu, J Ge, T Li, Y Shen, J Guo - Cancer Letters, 2019 - Elsevier
Abstract tRNA-derived fragments (tRFs) and tRNA halves (tiRNAs) are small non-coding
RNAs derived from precursor tRNAs or mature tRNAs. Depending on the sources, tRFs can …
RNAs derived from precursor tRNAs or mature tRNAs. Depending on the sources, tRFs can …
Effects of maternal and paternal exercise on offspring metabolism
J Kusuyama, AB Alves-Wagner, NS Makarewicz… - Nature …, 2020 - nature.com
Maternal and paternal obesity and type 2 diabetes are recognized risk factors for the
development of metabolic dysfunction in offspring, even when the offspring follow a healthful …
development of metabolic dysfunction in offspring, even when the offspring follow a healthful …