Introduction In light of the increased demand for reliable cancer-associated biomarkers and
ANLN oncogenic potential, the present study aimed to investigate ANLN's role in 24 human …

Background Aberrant methylation of DNA plays an important role in the pathogenesis of
nasopharyngeal carcinoma (NPC). In the current study, we aimed to integrate three cohorts …

The Cancer Genome Atlas (TCGA) provides a rich resource that can be used to understand
how genes interact in cancer cells and has collected RNA-Seq gene expression data for …

Background Osteosarcoma is one of the most prevalent bone malignancies with a poor
prognosis. The N7-methylguanosine (m7G) modification facilitates the modification of RNA …

Sorafenib, a multikinase inhibitor, has been widely used as a first-line anticancer drug for
advanced hepatocellular carcinoma (HCC). However, the development of drug resistance to …

Genomic imprinting plays an important role in growth and development. Loss of imprinting
(LOI) has been found in cancer, yet systematic studies are impeded by data-analytical …

The diversity and huge omics data take biology and biomedicine research and application
into a big data era, just like that popular in human society a decade ago. They are opening a …

Background Phosphoribosylaminoimidazole carboxylase (PAICS), a de novo purine
metabolic enzyme, has been identified as an oncogene in several tumor types, including …

Lung adenocarcinoma (LUAD) is a prevalent type of thoracic cancer with a poor prognosis
and high mortality rate. However, the exact pathogenesis of this cancer is still not fully …

Background: Although previous studies have identified the cervical cancer biomarkers by
utilizing gene expression omnibus (GEO) expression datasets, they are limited in their …