Background: Cancer is a multifactorial disease and the second leading cause of human
deaths worldwide. So far, the underlying mechanisms of cancer have not been yet fully …

Urothelial cancer, a common urinary system malignancy, often presents treatment
challenges due to metastasis and chemotherapy side effects. Angiogenesis, crucial for …

Acute myeloid leukemia (AML) is a malignant disorder of hemopoietic stem cells. AML can
escape immunosurveillance of natural killer (NK) by gene mutation, fusions and epigenetic …

Background BRCA1-associated protein 1 gene (BAP1) plays a key role in some cancers.
However, it has not yet been elucidated whether BAP1 modulates the pathogenesis and …

Due to its heterogeneous nature, head and neck squamous cell carcinoma (HNSC) had the
worst prognosis. Hence, there is an urgent need to develop novel diagnostic and prognostic …

Female cancers refer to malignant tumors of the female reproductive system and breasts,
which severely affect the physical and mental health of women. Although emerging …

Abstract Background Pituitary homeobox 1 (PITX1) is a member of the PITX gene family
which is vital to proper development of early embryo. However, the relationship of PITX1 …

Background The multifactorial nature of non-alcoholic fatty liver disease cannot be
explained solely by genetic factors. Recent evidence revealed that DNA methylation …

Introduction Mitochondrial dysfunction is common in cancer, and the mitochondrial electron
transport chain is often affected in carcinogenesis. So far, little is known about the …

Breast cancer is one of the most common cancer types which is described as the leading
cause of cancer death in women. After competitive endogenous RNA (ceRNA) hypothesis …