Next-generation sequencing technology has rapidly accelerated the discovery of genetic
variants of interest in individuals with rare diseases. However, showing that these variants …

Although gene discovery in neuropsychiatric disorders, including autism spectrum disorder,
intellectual disability, epilepsy, schizophrenia, and Tourette disorder, has accelerated …

During starvation, mammalian brains can adapt their metabolism, switching from glucose to
alternative peripheral fuel sources. In the Drosophila starved brain, memory formation is …

The anatomy of many neural circuits is being characterized with increasing resolution, but
their molecular properties remain mostly unknown. Here, we characterize gene expression …

A growing list of Alzheimer's disease (AD) genetic risk factors is being identified, but the
contribution of each variant to disease mechanism remains largely unknown. We have …

Recessive variants in GBA1 cause Gaucher disease, a prevalent form of lysosome storage
disease. GBA1 encodes a lysosomal enzyme that hydrolyzes glucosylceramide (GlcCer) …

The Drosophila ventral nerve cord (VNC) receives and processes descending signals from
the brain to produce a variety of coordinated locomotor outputs. It also integrates sensory …

We previously reported a CRISPR-mediated knock-in strategy into introns of Drosophila
genes, generating an attP-FRT-SA-T2A-GAL4-polyA-3XP3-EGFP-FRT-attP transgenic …

Oogenesis is a complex developmental process that involves spatiotemporally regulated
coordination between the germline and supporting, somatic cell populations. This process …

Neurotransmitters often have multiple receptors that induce distinct responses in receiving
cells. Expression and localization of neurotransmitter receptors in individual neurons are …