Neurochemical organization of the Drosophila brain visualized by endogenously tagged neurotransmitter receptors
S Kondo, T Takahashi, N Yamagata, Y Imanishi… - Cell Reports, 2020 - cell.com
Neurotransmitters often have multiple receptors that induce distinct responses in receiving
cells. Expression and localization of neurotransmitter receptors in individual neurons are …
cells. Expression and localization of neurotransmitter receptors in individual neurons are …
An expanded toolkit for Drosophila gene tagging using synthesized homology donor constructs for CRISPR-mediated homologous recombination
Previously, we described a large collection of Drosophila strains that each carry an artificial
exon containing a T2AGAL4 cassette inserted in an intron of a target gene based on …
exon containing a T2AGAL4 cassette inserted in an intron of a target gene based on …
A single-cell atlas of adult Drosophila ovary identifies transcriptional programs and somatic cell lineage regulating oogenesis
Oogenesis is a complex developmental process that involves spatiotemporally regulated
coordination between the germline and supporting, somatic cell populations. This process …
coordination between the germline and supporting, somatic cell populations. This process …
Loss-or gain-of-function mutations in ACOX1 cause axonal loss via different mechanisms
H Chung, MF Wangler, PC Marcogliese, J Jo… - Neuron, 2020 - cell.com
Summary ACOX1 (acyl-CoA oxidase 1) encodes the first and rate-limiting enzyme of the
very-long-chain fatty acid (VLCFA) β-oxidation pathway in peroxisomes and leads to H 2 O 2 …
very-long-chain fatty acid (VLCFA) β-oxidation pathway in peroxisomes and leads to H 2 O 2 …
Drosophila melanogaster: a simple genetic model of kidney structure, function and disease
Although the genetic basis of many kidney diseases is being rapidly elucidated, their
experimental study remains problematic owing to the lack of suitable models. The fruitfly …
experimental study remains problematic owing to the lack of suitable models. The fruitfly …
A single cell genomics atlas of the Drosophila larval eye reveals distinct photoreceptor developmental timelines
KK Bollepogu Raja, K Yeung, YK Shim, Y Li… - Nature …, 2023 - nature.com
The Drosophila eye is a powerful model system to study the dynamics of cell differentiation,
cell state transitions, cell maturation, and pattern formation. However, a high-resolution …
cell state transitions, cell maturation, and pattern formation. However, a high-resolution …
De novo variants in FRMD5 are associated with developmental delay, intellectual disability, ataxia, and abnormalities of eye movement
Proteins containing the FERM (four-point-one, ezrin, radixin, and moesin) domain link the
plasma membrane with cytoskeletal structures at specific cellular locations and have been …
plasma membrane with cytoskeletal structures at specific cellular locations and have been …
State-of-the-art CRISPR for in vivo and cell-based studies in Drosophila
J Zirin, J Bosch, R Viswanatha, SE Mohr, N Perrimon - Trends in Genetics, 2022 - cell.com
For more than 100 years, the fruit fly, Drosophila melanogaster, has served as a powerful
model organism for biological and biomedical research due to its many genetic and …
model organism for biological and biomedical research due to its many genetic and …
Bi-allelic variants in INTS11 are associated with a complex neurological disorder
The Integrator complex is a multi-subunit protein complex that regulates the processing of
nascent RNAs transcribed by RNA polymerase II (RNAPII), including small nuclear RNAs …
nascent RNAs transcribed by RNA polymerase II (RNAPII), including small nuclear RNAs …
Single‐cell RNA sequencing in Drosophila: Technologies and applications
H Li - Wiley Interdisciplinary Reviews: Developmental …, 2021 - Wiley Online Library
Single‐cell RNA sequencing (scRNA‐seq) has emerged as a powerful tool for investigating
cell states and functions at the single‐cell level. It has greatly revolutionized transcriptomic …
cell states and functions at the single‐cell level. It has greatly revolutionized transcriptomic …