Degeneration, trauma, and tumor resection are the main causes of bone loss (Owen et al., J.
Biomed. Mater. Res. B Appl. Biomater. 106 (6), 2493-2512 (2018), Korkusuz et al.,(2014) …

Simple Summary The Ras-Raf-MEK-ERK signaling pathway is responsible for regulating
cell proliferation, differentiation, and survival. Overexpression and overactivation of …

Intrinsically disordered proteins and regions (collectively, IDRs) are pervasive across
proteomes in all kingdoms of life, help to shape biological functions and are involved in …

ShcA (Src homologous-collagen homologue), family of adapter proteins, consists of three
isoforms which integrate and transduce external stimuli to different signaling networks. ShcA …

Oligodendrogliomas are brain tumors accounting for approximately 10% of all central
nervous system cancers. CIC is a transcription factor that is mutated in most patients with …

Symptoms of post-traumatic stress disorder (PTSD) are common in military populations, and
frequently associated with a history of combat-related mild traumatic brain injury (mTBI). In …

p66Shc is a widely expressed protein that governs a variety of cardiovascular pathologies
by generating, and exacerbating, pro-apoptotic ROS signals. Here, we review p66Shc's …

Mammalian macrophages can adopt polarization states that, depending on the exact stimuli
present in their extracellular environment, can lead to very different functions. Although …

Abstract Procollagen-lysine, 2-oxoglutarate 5-dioxygenases (PLODs) are a set of enzymes
involved in the hydroxylation of lysine and stabilization of collagen by crosslinks. Previous …

The aging process deteriorates organs' function at different levels, causing its progressive
decline to resist stress, damage, and disease. In addition to alterations in metabolic control …