P66Shc is the master regulator of oxidative stress whose pro-oxidant functioning is
governed by ser36 phosphorylation. Phosphorylated p66Shc via Rac1 GTPase activation …

Src homolog and collagen homolog binding protein 1 (SHCBP1) binds to the SH2 domain of
SHC‐transforming protein 1 (SHC1) and is involved in midbody organization and …

Exposure to intense or repeated stressors can lead to depression or post-traumatic stress
disorder (PTSD). Neurological changes induced by stress include impaired neurotrophin …

Src homolog and collagen homolog (Shc) proteins have been identified as adapter proteins
associated with cell surface receptors and have been shown to play important roles in …

Simple Summary Traditionally, chemotherapy has been approached through one-size-fits-
all strategies. However, personalized oncology would allow a rational approach to …

The development of hepatocellular carcinoma (HCC) is strongly associated with chronic
inflammation. p66Shc is an oxidase previously shown to promote androgen-independent …

Simple Summary Inactivating mutations in the CDH1 gene, encoding the cell adhesion
protein E-cadherin, cause hereditary diffuse gastric cancer syndrome (HDGC), as well as …

Caused by the pathogenic agent Mycobacterium bovis, bovine tuberculosis (bTB) is a major
concern in cattle breeding due to both its zoonotic potential and economic impact. Greater …

Growth hormone (GH) is a peptide hormone that plays a crucial role in controlling growth,
development, and lifespan. Molecular regulation of GH is accomplished via the GH receptor …

Oncostatin M (OSM), which belongs to the IL-6 family of cytokines, is the most potent and
effective stimulator of osteoclast formation in this family, as assessed by different in vitro …