The respiratory tree maintains sterilizing immunity against human fungal pathogens.
Humans inhale ubiquitous filamentous molds and geographically restricted dimorphic fungal …

Key Points Cryptococcal Disease in Diverse Hosts Worldwide, cryptococcal meningitis kills
up to 180,000 persons annually and is the most common cause of nonviral meningitis in the …

Fungal infections are a serious global concern because of their ability to spread and
colonize host tissues in immunocompromised individuals. Such infections have been …

Vaccination with glucan particles (GP) containing the Cryptococcus neoformans chitin
deacetylases Cda1 and Cda2 protect mice against experimental cryptococcosis. Here …

Cryptococcus neoformans and C. gattii, the etiologic agents of cryptococcosis, cause over
100,000 deaths worldwide every year, yet no cryptococcal vaccine has progressed to …

In recent years, fungal vaccine research emanated significant findings in the field of
antifungal T-cell immunity. The generation of effector T cells is essential to combat many …

Fungal infections represent a serious global health problem, causing damage to health and
the economy on the scale of millions. Although vaccines are the most effective therapeutic …

Glucan particles (GPs) are hollow, porous microspheres derived from Saccharomyces
cerevisiae (Baker's yeast). The hollow cavity of GPs allows for efficient encapsulation of …

Cryptococcus neoformans is an opportunistic human fungal pathogen causing lethal
meningoencephalitis. It has several cell wall mannoproteins (MPs) identified as …

Meningitis due to the fungal pathogen Cryptococcus neoformans is estimated to cause
nearly 200,000 deaths annually, mostly in resource-limited regions. We previously identified …