For many years, the dogma has been that insulin resistance precedes the development of
hyperinsulinemia. However, recent data suggest a reverse order and place …

Consistent evidence associates IGF-1 deficiency and metabolic syndrome. In this review, we
will focus on the metabolic effects of IGF-1, the concept of metabolic syndrome and its …

Body mass index, as an approximation of body adiposity, is associated with increased risk of
several common and less common malignancies in a sex-and site-specific manner. These …

Insulin-like growth factor-I (IGF-I) is closely related to insulin but has distinct metabolic
actions. IGF-I is an important stimulant of protein synthesis in muscle, but it also stimulates …

Cellular senescence is a fundamental aging mechanism that has been implicated in many
age-related diseases and is a significant cause of tissue dysfunction. Accumulation of …

Accumulating epidemiological evidence shows that being either overweight or obese, in
other words having excess body weight (EBW), is associated with an increased risk of …

The insulin-like growth factor (IGF) system is a complex network of two soluble ligands;
several cell surface transmembrane receptors and six soluble high-affinity binding-proteins …

Carrying excess body fat is a leading cause of cancer. Epidemiologic evidence gives strong
clues about the mechanisms that link excess adiposity to risk for several cancer sites. For …

Excess body weight (overweight and obesity) is characterized by chronic hyperinsulinaemia
and insulin resistance, and is implicated both in cancer risk and cancer mortality. The list of …

The prevalence of obesity, an established risk factor for many cancers, has risen steadily for
the past several decades in the United States and in many parts of the world. This review …