Publisher Summary The investigation of nutritional and other environmentally derived
influences in animal experiments has established that vast arrays of compounds are …

Enzymes of glutathione metabolism, particularly gamma-glutamyltransferase (GGT) and
glutathione S-transferase (GST), play a role in multistage hepatocarcinogenesis. The …

Hepatocyte nodules, structures consistently seen in every model of liver carcinogenesis well
before the first appearance of cancer, were examined with respect to some Phase I and …

Nous résumons brièvement les propriétés biochimiques reliées au métabolisme de
composés xénobiotiques dans des nodules hépatocytaires supposés prénéoplastiques. Il …

The concept that some types of cancer might be caused by environmental factors traces
back to the observation of the English physician Pott in the late 18th century that human …

Hepatocyte (“hyperplastic”) nodules induced in the liver by initiation with diethylnitrosamine
and selected by dietary 2-acetylaminofluorene plus partial hepatectomy (“resistant …

Biochemical 'markers' of neoplastic cells have been the subject of numerous investigations
during the past several decades. Recently, studies from a number of laboratories have …

Hepatocyte nodules that develop during the process of hepatocarcinogenesis in the rat,
using a multitude of different experimental protocols, are all resistant to the toxic effects of …

Studies were performed to test the hypothesis that urethane-induced murine lung tumors
exhibit xenobiotic resistance and alterations in pulmonary cytochrome P-450 enzymes. 1, 1 …

Phenobarbitone (PB) was administered to male C3H/He mice at a dose of 85 mg/kg/day in a
semisynthetic diet for up to 90 weeks. Throughout the treatment period a sustained induction …