Aim The current study aimed to develop enzyme-activated charge-reversal lipid
nanoparticles (LNPs) as novel gene delivery systems. Methods Palmitic acid was covalently …

Nucleophilic amino acids play important roles in maintenance of protein structure and
function, covalent modification of such amino acid residues by therapeutic agents is an …

Chemical probes are invaluable tools to investigate biological processes and can serve as
lead molecules for the development of new therapies. However, despite their utility, only a …

The S‐alkylation of Cys residues with a maleimide and the Nϵ‐acylation of Lys residues
with an N‐hydroxysuccinimide (NHS) ester are common methods for bioconjugation. Using …

A fluorescent probe for the detection of lead ions in complete aqueous solution was
synthesized by covalently combining a fluorescent 1, 8-naphthalimide dye with cellulose …

The “inverse drug discovery” strategy is a potent means of exploring the cellular targets of
latent electrophiles not typically used in medicinal chemistry. Cyclopropenone, a powerful …

Chemical genetics is a powerful approach for identifying therapeutically active small
molecules, but identifying the mechanisms of action underlying hit compounds remains …

Herbicides in the widely used chloroacetanilide class harbor a potent electrophilic moiety,
which can damage proteins through nucleophilic substitution. In general, damaged proteins …

Aim The aim of the study was to evaluate the effect of thiolation of lipid-based nanoparticles
(LNPs) on cellular uptake of nucleic acids. Methods A thiolated surfactant was synthesized …

The ubiquitin system contains a wealth of potential drug targets for many diseases and
conditions, including neurodegenerative, immune, metabolic and developmental diseases …