Covalent ligand discovery is a promising strategy to develop small-molecule effectors
against therapeutic targets. Recent studies have shown that dichlorotriazines are promising …

Microcystins, cyclic nonribosomal heptapeptides, are the most well-known cyanobacterial
toxins. They are exceptionally well studied, but open questions remain concerning their …

Recently, numerous efforts have been devoted to identifying drug targets and binding sites
in complex proteomes, which is of great importance in modern drug discovery. In this study …

Environmental agents of exposure can damage proteins, affecting protein function and
cellular protein homeostasis. Specific residues are inherently chemically susceptible to …

The use of light‐responsive proteins to control both living or synthetic cells, is at the core of
the expanding fields of optogenetics and synthetic biology. It is thus apparent that a richer …

Alkynes are a key component of click chemistry and used for a wide variety of applications
including bioconjugation, selective tagging of protein modifications, and labeling of …

Dysregulated oxidative stress plays a major role in cancer pathogenesis and some types of
cancer cells are particularly vulnerable to inhibition of their cellular antioxidant capacity …

The functionalization of proteins with DNA through the formation of covalent bonds enables
a wide range of biotechnology advancements. For example, single-molecule analytical …

Natural systems produce various γ-dicarbonyl-bearing compounds that can covalently
modify lysine in protein targets via the classic Paal–Knorr reaction. Among them is a unique …

Reactive cysteines often serve as functional sites on proteins and play important regulatory
roles in various biological processes. A chemoproteomic method named “isoTOP‐ABPP” …