ortho-Phthalaldehyde (OPA) with high reactivity to the amine group has been widely used to
modify proteins. We discovered new modifications of OPA and 2-acylbenzaldehyde and …

Chemical proteomics, which involves studying the covalent modifications of proteins by
small molecules, has significantly contributed to our understanding of protein function and …

Recent advances in drug development and bioactive molecules that covalently target lysine
residues have shown substantial progress. Both reversible and irreversible covalent …

Activity‐based proteomic profiling (ABPP) enables the functional study of enzymes by
employing small molecule probes that bind covalently to the active site of an enzyme …

Chemical methods that provide a readout of biochemical changes within a cell at the protein
level enable precise characterization of biological phenotypes that may not always be …

Attaching proteins to surfaces while maintaining bioactivity is a promising avenue for
developing new functional materials. This work describes a method to rapidly apply …

Covalent modification of endogenous proteins by chemical probes is used for proteome-
wide profiling of cellular protein function and drug discovery. However, probe selectivity in …

Drug discovery involving covalent drugs has a rich history dating back to the 20th century.
Despite their longevity, concerns about safety have relegated covalent drug development to …

Alkyne tags have been widely used for the enrichment of labeled proteins to enable their
profiling at a proteome‐wide scale by mass spectrometry. The key component in the …

S. aureus associated bacteremia can lead to severe infections with high risk of mortality (eg
sepsis, infective endocarditis). Many virulence factors and adhesins of S. aureus are known …