Abstract A Morita‐Baylis‐Hillman Adduct (MBHA) derivative bearing a triphenylamine moiety
was found to react with human serum albumin (HSA) shifting its emission from the blue to …

Bioactive small molecules that form covalent bonds with a target protein are important tools
for basic research and can be highly effective drugs. This review highlights reactive groups …

Introduction Labeling single domain antibody fragments (sdAbs) with 18 F is an attractive
strategy for immunoPET. Earlier, we developed a residualizing label, N-succinimidyl 3-((4-(4 …

Hyaluronic acid (HA) is a mucopolysaccharide alternately linked by glucuronic acid and n-
Acetylglucosamine as disaccharide units. This study prepared HA derivative (DA-HA) by …

Ophiobolin A (OPA) is a sesterterpenoid fungal natural product with broad anti-cancer
activity. While OPA possesses multiple electrophilic moieties that can covalently react with …

原创药物的研制得益于蛋白质新靶标的发现, 而新靶标的发现依赖于高可信度、 高通量的药物-
蛋白质相互作用分析方法。 蛋白质作为生命功能的执行者, 其表达量、 空间定位与结构差异直接 …

Covalent modifications of nonactive site lysine residues by small molecule probes has
recently evolved into an important strategy for interrogating biological systems. Here, we …

It is known that the crystallizability of protein molecules may be improved by replacing their
surface lysine residues with other residue types. Here an experimental method to identify …

Secondary metabolites are structurally diverse natural products (NPs) and have been widely
used for medical applications. Developing new tools to enrich NPs can be a promising …

Activity‐based protein profiling (ABPP) is a chemical proteomic method for investigating
functional states of proteins in native biological settings. By quantifying changes in probe …