There has been a surge of interest and efforts in the discovery of covalent ligands for diverse
proteins as tool compounds or therapeutic candidates in recent years. We present two …

The utilities of an α‐methylene‐β‐lactone (MeLac) moiety as a warhead composed of
multiple electrophilic sites are reported. We demonstrate that a MeLac‐alkyne not only …

Proteins play a central role in most biological processes within the cell and deciphering how
they interact is key to understand their function. Cross-linking coupled to mass spectrometry …

Chemical modification of proteins has emerged as a powerful tool to realize enormous
applications, such as development of novel biologics and functional studies of individual …

Covalent inhibitors are emerging as a promising therapeutic means for efficient and
sustained targeting of key disease-driving proteins. As for classic non-covalent inhibitors …

Since the concept of oxidative stress was added to the field of redox biology and medicine in
1985, 1 the issues of oxidative stress have been evolving in physiology and …

Targeted protein therapeutics have garnered significant interest in modern drug discovery,
in part due to their ability to target classically “undruggable” proteins.“Undruggable” proteins …

Yeni ilaç arayışı için, hedeflendirilmiş kovalent inhibitörler büyük umut vaadeder. Geleneksel
tersinir inhibitörlere göre, genişletilmiş alıkonma süresi ve arttırılmış potansiyele sahip …

Covalent drugs incorporate a mildly electrophilic functional group that reacts with protein
targets to confer additional affinity beyond the non-covalent interactions involved in drug …

The electrochemical quantification of protein biomarkers from complex samples such as
human serum promises vast potential for the solution of future healthcare challenges …