Design of experiment (DoE) as a quality by design (QbD) tool to optimise formulations of lipid nanoparticles for nose-to-brain drug delivery
AC Correia, JN Moreira, JM Sousa Lobo… - Expert Opinion on Drug …, 2023 - Taylor & Francis
Introduction The nose-to-brain route has been widely investigated to improve drug targeting
to the central nervous system (CNS), where lipid nanoparticles (solid lipid nanoparticles …
to the central nervous system (CNS), where lipid nanoparticles (solid lipid nanoparticles …
Versatile Nanoparticulate Systems as a Prosperous Platform for Targeted Nose–Brain Drug Delivery
The intranasal route has proven to be a reliable and promising route for delivering
therapeutics to the central nervous system (CNS), averting the blood–brain barrier (BBB) …
therapeutics to the central nervous system (CNS), averting the blood–brain barrier (BBB) …
Rivastigmine-DHA ion-pair complex improved loading in hybrid nanoparticles for better amyloid inhibition and nose-to-brain targeting in Alzheimer's
Rivastigmine hydrogen tartrate (RIV-HT) is given orally for Alzheimer's disease. However,
oral therapy shows low brain bioavailability, short half-life and gastrointestinal-mediated …
oral therapy shows low brain bioavailability, short half-life and gastrointestinal-mediated …
Novel pyridine bearing pentose moiety-based anticancer agents: Design, synthesis, radioiodination and bioassessments
MM Mehany, OA Hammam, AA Selim, GH Sayed… - Scientific Reports, 2024 - nature.com
Pyridine compounds are one of the most important heterocyclic derivatives showing wide
ranges in biological and pharmacological activities. Green chemistry eliminates or reduces …
ranges in biological and pharmacological activities. Green chemistry eliminates or reduces …
Nose to brain delivery of mirtazapine via lipid nanocapsules: Preparation, statistical optimization, radiolabeling, in vivo biodistribution and pharmacokinetic study
MM Ibrahim, EB Basalious, MA El-Nabarawi… - Drug Delivery and …, 2024 - Springer
Mirtazapine (MZPc) is an antidepressant drug which is approved by the FDA. It has low
bioavailability, which is only 50%, in spite of its rapid absorption when orally administered …
bioavailability, which is only 50%, in spite of its rapid absorption when orally administered …
pH-Sensitive doxorubicin delivery using zinc oxide nanoparticles as a rectified theranostic platform: in vitro anti-proliferative, apoptotic, cell cycle arrest and in vivo …
MM Swidan, F Marzook, TM Sakr - Journal of Materials Chemistry B, 2024 - pubs.rsc.org
Despite enormous advancements in its management, cancer is the world's primary cause of
mortality. Therefore, tremendous strides were made to produce intelligent theranostics with …
mortality. Therefore, tremendous strides were made to produce intelligent theranostics with …
Investigating the potential of highly porous zopiclone-loaded 3D electrospun nanofibers for brain targeting via the intranasal route
Nanofibers (NFs) have proven to be very attractive tool as drug delivery plateform among the
different plethora of nanosystems, owing to their unique features. They exhibit two-and three …
different plethora of nanosystems, owing to their unique features. They exhibit two-and three …
Combining the potential of 3D printed buccal films and nanostructured lipid carriers for personalised cannabidiol delivery
Cannabidiol (CBD) has been recognized for its numerous therapeutic benefits, such as
neuroprotection, anti-inflammatory effects, and cardioprotection. However, CBD has some …
neuroprotection, anti-inflammatory effects, and cardioprotection. However, CBD has some …
Oral in vivo biodistribution of fluorescent labelled nanolipid carrier system of erlotinib using real time optical imaging technique
P Kumar, B Mangla, SA Imam, G Aggarwal - International Journal of …, 2024 - Elsevier
This study investigates the biodistribution of a nano lipid carrier system (NLCs) containing
the hydrophobic drug erlotinib (ERL-NLCs). The system was labelled with the fluorescent …
the hydrophobic drug erlotinib (ERL-NLCs). The system was labelled with the fluorescent …
An intelligent and self-assembled nanoscale metal organic framework (99mTC-DOX loaded Fe3O4@FeIII-tannic acid) for tumor targeted chemo/chemodynamic …
Background Recent advances in clinical transformation research have focused on
chemodynamic theranostics as an emerging strategy for tackling cancer. Nevertheless, its …
chemodynamic theranostics as an emerging strategy for tackling cancer. Nevertheless, its …