Epitope-based vaccine design: a comprehensive overview of bioinformatics approaches
Highlights•Epitope vaccines provide maximal therapeutic efficacy with minimal side
effects.•Reverse vaccinology can be used for designing epitope vaccines.•Computational …
effects.•Reverse vaccinology can be used for designing epitope vaccines.•Computational …
A guide to current methodology and usage of reverse vaccinology towards in silico vaccine discovery
SJ Goodswen, PJ Kennedy… - FEMS Microbiology …, 2023 - academic.oup.com
Reverse vaccinology (RV) was described at its inception in 2000 as an in silico process that
starts from the genomic sequence of the pathogen and ends with a list of potential protein …
starts from the genomic sequence of the pathogen and ends with a list of potential protein …
[HTML][HTML] COVID-19 coronavirus vaccine design using reverse vaccinology and machine learning
To ultimately combat the emerging COVID-19 pandemic, it is desired to develop an effective
and safe vaccine against this highly contagious disease caused by the SARS-CoV-2 …
and safe vaccine against this highly contagious disease caused by the SARS-CoV-2 …
[HTML][HTML] In silico analysis of epitope-based vaccine candidate against tuberculosis using reverse vaccinology
Tuberculosis (TB) kills more individuals in the world than any other disease, and a threat
made direr by the coverage of drug-resistant strains of Mycobacterium tuberculosis (Mtb) …
made direr by the coverage of drug-resistant strains of Mycobacterium tuberculosis (Mtb) …
[HTML][HTML] Identification of vaccine targets in pathogens and design of a vaccine using computational approaches
Antigen identification is an important step in the vaccine development process.
Computational approaches including deep learning systems can play an important role in …
Computational approaches including deep learning systems can play an important role in …
Designing of a multi-epitope vaccine against the structural proteins of marburg virus exploiting the immunoinformatics approach
Marburg virus disease (MVD) caused by the Marburg virus (MARV) generally appears with
flu-like symptoms and leads to severe hemorrhagic fever. It spreads via direct contact with …
flu-like symptoms and leads to severe hemorrhagic fever. It spreads via direct contact with …
Vaxign2: the second generation of the first Web-based vaccine design program using reverse vaccinology and machine learning
E Ong, MF Cooke, A Huffman, Z Xiang… - Nucleic acids …, 2021 - academic.oup.com
Vaccination is one of the most significant inventions in medicine. Reverse vaccinology (RV)
is a state-of-the-art technique to predict vaccine candidates from pathogen's genome (s). To …
is a state-of-the-art technique to predict vaccine candidates from pathogen's genome (s). To …
Vaxign-ML: supervised machine learning reverse vaccinology model for improved prediction of bacterial protective antigens
E Ong, H Wang, MU Wong, M Seetharaman… - …, 2020 - academic.oup.com
Motivation Reverse vaccinology (RV) is a milestone in rational vaccine design, and machine
learning (ML) has been applied to enhance the accuracy of RV prediction. However, ML …
learning (ML) has been applied to enhance the accuracy of RV prediction. However, ML …
Immunoinformatics-guided design of an epitope-based vaccine against severe acute respiratory syndrome coronavirus 2 spike glycoprotein
A Rakib, SA Sami, NJ Mimi, MM Chowdhury… - Computers in biology …, 2020 - Elsevier
Aims With a large number of fatalities, coronavirus disease-2019 (COVID-19) has greatly
affected human health worldwide. Severe acute respiratory syndrome coronavirus 2 (SARS …
affected human health worldwide. Severe acute respiratory syndrome coronavirus 2 (SARS …
[HTML][HTML] Designing a Recombinant Vaccine against Providencia rettgeri Using Immunoinformatics Approach
Antibiotic resistance (AR) is the resistance mechanism pattern in bacteria that evolves over
some time, thus protecting the bacteria against antibiotics. AR is due to bacterial evolution to …
some time, thus protecting the bacteria against antibiotics. AR is due to bacterial evolution to …