[HTML][HTML] Identification of shared and disease-specific host gene–microbiome associations across human diseases using multi-omic integration
While gut microbiome and host gene regulation independently contribute to gastrointestinal
disorders, it is unclear how the two may interact to influence host pathophysiology. Here we …
disorders, it is unclear how the two may interact to influence host pathophysiology. Here we …
[HTML][HTML] The epigenetic reader methyl-CpG-binding protein 2 (MeCP2) is an emerging oncogene in cancer biology
K Nejati-Koshki, CT Roberts, G Babaei, M Rastegar - Cancers, 2023 - mdpi.com
Simple Summary Methyl-CpG binding protein 2 (MeCP2) is a nuclear protein that is mainly
studied for its role as an epigenetic regulator of gene transcription. Gene mutations affecting …
studied for its role as an epigenetic regulator of gene transcription. Gene mutations affecting …
MirDIP 5.2: tissue context annotation and novel microRNA curation
AC Hauschild, C Pastrello, GKA Ekaputeri… - Nucleic Acids …, 2023 - academic.oup.com
MirDIP is a well-established database that aggregates microRNA-gene human interactions
from multiple databases to increase coverage, reduce bias, and improve usability by …
from multiple databases to increase coverage, reduce bias, and improve usability by …
[HTML][HTML] Nuclear receptor coregulators in hormone-dependent cancers
Simple Summary Altered nuclear receptor signaling is well-established to contribute to a
range of hormone-dependent cancers and therefore they are therapeutic targets, for …
range of hormone-dependent cancers and therefore they are therapeutic targets, for …
[HTML][HTML] SPI1-induced downregulation of FTO promotes GBM progression by regulating pri-miR-10a processing in an m6A-dependent manner
S Zhang, S Zhao, Y Qi, B Li, H Wang, Z Pan… - … Therapy-Nucleic Acids, 2022 - cell.com
As one of the most common post-transcriptional modifications of mRNAs and noncoding
RNAs, N 6-methyladenosine (m 6 A) modification regulates almost every aspect of RNA …
RNAs, N 6-methyladenosine (m 6 A) modification regulates almost every aspect of RNA …
Methyl CpG binding protein 2 promotes colorectal cancer metastasis by regulating N6‐methyladenosine methylation through methyltransferase‐like 14
S Wang, M Gan, C Chen, Y Zhang, J Kong… - Cancer …, 2021 - Wiley Online Library
Abstract RNA N6‐methyladenosine (m6A) is an emerging regulatory mechanism for tumor
progression in several types of cancer. However, the underlying regulation mechanisms of …
progression in several types of cancer. However, the underlying regulation mechanisms of …
Methylated Nucleotide-Based Proteolysis-Targeting Chimera Enables Targeted Degradation of Methyl-CpG-Binding Protein 2
Methyl-CpG-binding protein 2 (MeCP2), a reader of DNA methylation, has been extensively
investigated for its function in neurological and neurodevelopmental disorders. Emerging …
investigated for its function in neurological and neurodevelopmental disorders. Emerging …
MeCP2 drives hepatocellular carcinoma progression via enforcing HOXD3 promoter methylation and expression through the HB‐EGF/EGFR pathway
L Wang, Y Gao, D Tong, X Wang, C Guo… - Molecular …, 2021 - Wiley Online Library
Homeobox D3 (HOXD3), a member of the homeobox family, was described to regulate
tumorigenesis, invasion, metastasis, and angiogenesis in various tumor types. However, the …
tumorigenesis, invasion, metastasis, and angiogenesis in various tumor types. However, the …
[HTML][HTML] MIR503HG impeded ovarian cancer progression by interacting with SPI1 and preventing TMEFF1 transcription
J Tian, L Yang, Z Wang, H Yan - Aging (Albany NY), 2022 - ncbi.nlm.nih.gov
Abstract MIR503 host gene (MIR503HG) acts as an important tumor suppressor in many
human cancers, but its role and regulatory mechanism in ovarian cancer need to be further …
human cancers, but its role and regulatory mechanism in ovarian cancer need to be further …
IRF1 suppresses colon cancer proliferation by reducing SPI1-mediated transcriptional activation of GPX4 and promoting ferroptosis
Y Chen, B Lin, S Yang, J Huang - Experimental Cell Research, 2023 - Elsevier
IRF1 is a tumor suppressor gene in colon cancer. This study aimed to explore the potential
regulation of IRF1 on the ferroptosis of colon cancer and the mechanisms underlying its …
regulation of IRF1 on the ferroptosis of colon cancer and the mechanisms underlying its …