Design, synthesis, in silico studies, and biological evaluation of novel pyrimidine-5-carbonitrile derivatives as potential anti-proliferative agents, VEGFR-2 inhibitors …
AM Saleh, HA Mahdy, MA El-Zahabi, ABM Mehany… - RSC …, 2023 - pubs.rsc.org
A novel series of pyrimidine-5-carbonitrile derivatives bearing benzylidene and hydrazone
moieties with different linkers (spacers) were designed and synthesized as possible …
moieties with different linkers (spacers) were designed and synthesized as possible …
Design, synthesis, and biological evaluation of new pyrimidine-5-carbonitrile derivatives as novel anti-cancer, dual EGFR WT/COX-2 inhibitors with docking studies
A novel series of pyrimidine-5-carbonitrile derivatives was designed, synthesized, then
evaluated for their cytotoxic activity as novel anti-cancer with dual EGFRWT/COX-2 …
evaluated for their cytotoxic activity as novel anti-cancer with dual EGFRWT/COX-2 …
Discovery of new thiazolidine-2, 4-dione derivatives as potential VEGFR-2 inhibitors: In vitro and in silico studies
In this study, a series of seven novel 2, 4-dioxothiazolidine derivatives with potential
anticancer and VEGFR-2 inhibiting abilities were designed and synthesized as VEGFR-2 …
anticancer and VEGFR-2 inhibiting abilities were designed and synthesized as VEGFR-2 …
Hydrophobicity, Transport and Target Sites of Action Are Important for the Activity of Many Drugs
RR Ayyad, AM Nejm, YH Abdelaleem… - Current Research in …, 2023 - pioneerpublisher.com
The Hydrophobicity mean the compounds which insoluble in water ie, hate the water (not
love the water). May be these compounds are lipid soluble, but not actually. This means …
love the water). May be these compounds are lipid soluble, but not actually. This means …
Pyrimidine-5-carbonitriles: A review of available synthetic approaches and biological evaluation for promising compounds over the last decade
ME Adly, NA Edris, HH Kadry… - Egyptian Journal of …, 2024 - journals.ekb.eg
The structural diversity and biological significance of pyrimidine core attracted the attention
of many researchers and scientists in the past years owing to their inclusion in the …
of many researchers and scientists in the past years owing to their inclusion in the …
Visible‐Light Induced Trifluoromethylation/Cyclization of Unactivated Alkene‐Bound Quinazolinones
L Zou, H Zhao, X Wang, J Dong, C Yang… - European Journal of …, 2024 - Wiley Online Library
Herein, we reported a selective, mild method for the visible‐light‐photocatalyzed
trifluoromethylation and cyclization of unactivated tethered alkenes to provide tri‐and …
trifluoromethylation and cyclization of unactivated tethered alkenes to provide tri‐and …
Mechanism of Action of Many Drugs Depend on Enzyme Inhibition
RR Ayyad, AM Nejm, YAA Hassan… - Current Research in …, 2023 - pioneerpublisher.com
Enzyme inhibition is an important process in the mode of action of many drugs used in the
treatment of various diseases. Antibiotics, anti-hypertensive agents, anti-hyperlipidaemic …
treatment of various diseases. Antibiotics, anti-hypertensive agents, anti-hyperlipidaemic …
Overview on Some Drugs Act on DNA and RNA Other than Anti-Viral Drugs—The Direct Cholinomimetics and Cholinergic Blocking Agents Depend on Stereo …
RR Ayyad, AM Mansour, AM Nejm… - Current Research in …, 2024 - pioneerpublisher.com
Overview on Some Drugs Act on DNA and RNA Other than Anti-Viral Drugs — The Direct
Cholinomimetics and Cholinergic Blocking Ag Page 1 20 Overview on Some Drugs Act on …
Cholinomimetics and Cholinergic Blocking Ag Page 1 20 Overview on Some Drugs Act on …
[PDF][PDF] An Overview of Antibiotics Used in Cancer Treatment and Drugs that Act as Antimicrotubules
RR Ayyad, AM Mansour, AM Nejm… - Journal of Progress …, 2024 - pioneerpublisher.com
An Overview of Antibiotics Used in Cancer Treatment and Drugs that Act as
Antimicrotubules Page 1 25 An Overview of Antibiotics Used in Cancer Treatment and …
Antimicrotubules Page 1 25 An Overview of Antibiotics Used in Cancer Treatment and …
The Lipid Solubility of Most Drugs Play Important Role of Its Pharmacological Action and Duration of Action
RR Ayyad, AM Nejm, YAA Hassan… - Journal of Progress in …, 2023 - pioneerpublisher.com
The Lipid Solubility of Most Drugs Play Important Role of Its Pharmacological Action and Duration
of Action Page 1 1 The Lipid Solubility of Most Drugs Play Important Role of Its Pharmacological …
of Action Page 1 1 The Lipid Solubility of Most Drugs Play Important Role of Its Pharmacological …