Fibromyalgia is a syndrome characterized by chronic and widespread musculoskeletal pain,
often accompanied by other symptoms, such as fatigue, intestinal disorders and alterations …

Fibromyalgia (FM) is a syndrome that does not present a well-defined underlying organic
disease. FM is a condition which has been associated with diseases such as infections …

Chronic pain is nowadays used as an umbrella term referring to a wide range of clinical
conditions, such as fibromyalgia, migraine, or long-standing pain states without actual …

Abstract The World Health Organization regards chronic pain to be a public health concern.
In clinical medicine, fibromyalgia (FM) is the most prevalent chronic widespread pain …

Fibromyalgia (FM) is a serious chronic pain syndrome, characterised by muscle and joint
stiffness, insomnia, fatigue, mood disorders, cognitive dysfunction, anxiety, depression and …

Chronic pain represents one of the most serious worldwide medical problems, in terms of
both social and economic costs, often causing severe and intractable physical and …

This paper is the forty-fifth consecutive installment of the annual anthological review of
research concerning the endogenous opioid system, summarizing articles published during …

The observation of the immunomodulatory effects of opioid drugs opened the discussion
about possible mechanisms of action and led researchers to consider the presence of opioid …

Neuropathic pain is a chronic painful disease. Data have shown that reactive oxygen
species (ROS) are implicated in chronic pain. Particularly, the enhanced ROS production …

Opioids are excellent analgesics for the clinical treatment of various types of acute and
chronic pain, particularly cancer-related pain. Nevertheless, it is well known that opioids …