Cholesterol/sphingolipid-rich membrane domains, known as lipid rafts or membrane rafts,
play a critical role in the compartmentalization of signaling pathways. Physical segregation …

Drug discovery from marine natural products has enjoyed a renaissance in the past few
years. Ziconotide (Prialt; Elan Pharmaceuticals), a peptide originally discovered in a tropical …

Plants, marine organisms, and microorganisms have evolved complex chemical defense
and signaling systems that are designed to protect them from predators and provide other …

Microtubules are dynamic polymers that play crucial roles in a large number of cellular
functions. Their pivotal role in mitosis makes them a target for the development of anticancer …

This present study reviewed the chemical diversity of marine ascidians and their
pharmacological applications, challenges and recent developments in marine drug …

Multiple myeloma (MM) is an incurable B-cell malignancy, requiring new therapeutic
strategies. We have found that synthetic alkyl-lysophospholipids (ALPs) edelfosine and …

While investigating the mechanism of action of the novel antitumor drug Aplidin, we have
discovered a potent and novel cell-killing mechanism that involves the formation of …

The development of new drugs able to directly activate the apoptotic machinery in tumors is
a promising approach in the treatment of cancer as it is independent of sensors and …

Marine ecosystems contain over 80% of the world's biodiversity, and many of these
organisms have evolved unique adaptations enabling survival in diverse and challenging …

Abstract eEF1A2 is one of the isoforms of the alpha subunit of the eukaryotic Elongation
Factor 1. It is overexpressed in human tumors and is endowed with oncogenic properties …