The dearth of new medicines effective against antibiotic-resistant bacteria presents a
growing global public health concern. For more than five decades, the search for new …

We report the design conception, chemical synthesis, and microbiological evaluation of the
bridged macrobicyclic antibiotic cresomycin (CRM), which overcomes evolutionarily diverse …

The bacterial ribosome is an essential drug target as many clinically important antibiotics
bind and inhibit its functional centers. The catalytic peptidyl transferase center (PTC) is …

Since antibiotic resistance is often associated with a fitness cost, bacteria employ multi-
layered regulatory mechanisms to ensure that expression of resistance factors is restricted to …

Lincosamides are naturally occurring antibiotics isolated from Streptomyces sp. Currently,
lincomycin A and its semisynthetic analogue clindamycin are used as clinical drugs. Due to …

The golden age of antibiotic discovery was marked not only by the discovery of numerous
new antibiotic structures but also by the recurring correlation of these antibiotics to two …

Background Listeriosis is a food-borne disease caused by the Gram-positive Bacillota
(Firmicute) bacterium Listeria monocytogenes. Clinical L. monocytogenes isolates are often …

Hydrogen-tritium exchange is widely employed for radioisotopic labeling of molecules of
biological interest but typically involves the metal-promoted exchange of sp 2-hybridized …

The ribosome is an essential drug target as many classes of clinically important antibiotics
bind and inhibit its functional centers. The catalytic peptidyl transferase center (PTC) is …

In this work, the synthetic development of an oxime resin aminolysis to lincosamide
analogues is described. This synthetic endeavor hinges on a protecting-group-free strategy …