Lymph node fibroblastic reticular cells (FRCs) respond to signals from activated T cells by
releasing nitric oxide, which inhibits T cell proliferation and restricts the size of the …

CD4 T cell help is critical to sustain effector CD8 T cell responses during chronic infection,
notably via T follicular helper (Tfh)-derived interleukin-21 (IL-21). Conversely, CD4 depletion …

In type 1 diabetes (T1D) autoreactive CD8 T cells infiltrate pancreatic islets and destroy
insulin-producing β cells. Progression to T1D onset is a chronic process, which suggests …

With the emergence and success of checkpoint blockade immunotherapy, immuno-oncology
has primarily focused on CD8 T cells, whose cytotoxic programs directly target tumor cells …

Abstract Chronic Epstein-Barr virus (EBV) infection after pediatric organ transplantation (Tx)
accounts for significant morbidity and mortality. The risk of complications, such as …

Persistent antigenic stimulation results in loss of effector function or physical deletion of
antigen-specific CD8 T cells. This T-cell state is called T-cell exhaustion and occurs during …

Background CD8+ T cells equipped with a full arsenal of antiviral effector functions are
critical for effective immune control of HIV-1. It has nonetheless remained unclear how best …

Upon resolution of an acute viral infection, during latent‐reactivating infection and during
chronic active infections virus‐specific T‐cells differentiate into distinct subsets that differ in …

B and T cell responses were evaluated in patients with rheumatoid arthritis (RA) or psoriatic
arthritis (PsA) after 1 or 2 weeks of methotrexate (MTX) withdrawal following each COVID-19 …

CD8+ T cells are preprogrammed for cytotoxic differentiation in the thymus as they acquire
expression of the transcription factor Runx3. However, a subset of effector CD8+ T cells …