Nephrotic syndrome (NS) is the most frequent cause of proteinuria in children and is
emerging as a leading cause of uremia. Molecular studies in families with recessive NS …

Focal segmental glomerulosclerosis (FSGS) is a major cause of idiopathic steroid-resistant
nephrotic syndrome (SRNS) and end-stage kidney disease (ESKD). In recent years, animal …

Proteinuria is a poorly understood feature of many acquired renal diseases. Recent studies
concerning congenital nephrotic syndromes and findings in genetically modified mice have …

A total of 179 children with sporadic nephrotic syndrome were screened for podocin
mutations: 120 with steroid resistance, and 59 with steroid dependence/frequent relapses …

Background. The rate of complete remission after induction therapy for steroid-resistant
nephrotic syndrome (SRNS) due to either focal segmental glomerulosclerosis (FSGS) or …

Focal segmental glomerulosclerosis (FSGS), a subtype of'idiopathic nephrotic syndrome', is
not a single disease, but a lesion that initially affects the glomerulus followed by the …

Focal segmental glomerulosclerosis (FSGS) is characterized by steroid resistant nephrotic
syndrome and progression to end-stage renal disease. Proteinuria in certain patients with …

Abstract Nuclear Factor-κB (NF-κB) has been suggested to play a role in the cellular and
molecular mechanisms underlying glomerular injury. We investigated the potential role of …

Background: Nephrotic syndrome (NS) develops most commonly in people with glomerular
diseases associated with marked albuminuria. Hypernatremia, hypertension, and …

Background: Prolonged treatment with steroids and/or cyclophosphamide improves the
prognosis of primary focal segmental glomerulosclerosis (FSGS). In nephrotic patients, no …