Febuxostat (FBX), a xanthine oxidase inhibitor, is known to improve renal function and can
show promise as a therapeutic agent for preventing drug-induced nephrotoxicity. This study …

Liver dysfunction in sepsis is a major complication that amplifies multiple organ failure and
increases the risk of death. Inflammation and oxidative stress are the main mediators in the …

Abstract Aloe marlothii A. Berger (AM), one of the most iconic aloes native to South Africa.
Several evidence-based reports on its bioactivities were explored as digestive …

Sepsis-related global mortality remains unacceptably high in intensive care units. Identifying
the various molecular processes between survival and death in septic patients may assist in …

Background This research was to investigate the mechanism of neutrophil elastase (NE) in
dexmedetomidine (DEX) alleviates sepsis-related renal injury in rats. Methods Sixty healthy …

Xanthine oxidase (XO) utilizes molecular oxygen as a substrate to convert purine substrates
into uric acid, superoxide, and hydrogen peroxide, which is one of the main enzyme …

Objectives We investigated, the effects of aprepitant (APRE) on the lung tissues of rats with
an experimental polymicrobial sepsis model (CLP: cecal ligation and puncture) …

In this study, the protective effect of melatonin was investigated in lipopolysaccharide
induced sepsis model. Twenty‐eight rats were randomly divided: Control, Melatonin, LPS …

Background Vancomycin (VCM) is used clinically to treat serious infections caused by multi-
resistant Gram-positive bacteria, although its use is severely constrained by nephrotoxicity …

Sepsis, a life-threatening condition resulting from an uncontrolled host response to infection,
often leads to severe liver damage and remains a significant cause of mortality in critically ill …