The role of intestinal flora and its metabolites in heart failure

X Guan, Z Sun - Infection and drug resistance, 2023 - Taylor & Francis
Intestinal flora is a complex collection of microbial communities that participate in the
physiological and pathological activities of the human body through various pathways. In …

[HTML][HTML] The interaction of gut microbiota and heart failure with preserved ejection fraction: from mechanism to potential therapies

W Yu, Y Jiang, H Xu, Y Zhou - Biomedicines, 2023 - mdpi.com
Heart failure with preserved ejection fraction (HFpEF) is a disease for which there is no
definite and effective treatment, and the number of patients is more than 50% of heart failure …

[HTML][HTML] Integration of transcriptomics, metabolomics, and lipidomics reveals the mechanisms of doxorubicin-induced inflammatory responses and myocardial …

X Tan, R Zhang, M Lan, C Wen, H Wang, J Guo… - Biomedicine & …, 2023 - Elsevier
Doxorubicin (DOX) is an anthracycline antineoplastic agent that has limited clinical utility
due to its dose-dependent cardiotoxicity. Although the exact mechanism remains unknown …

Shengmai Yin formula exerts cardioprotective effects on rats with chronic heart failure via regulating linoleic acid metabolism

S Wang, J Gan, J Li, Y Wang, J Zhang, L Song… - Prostaglandins & Other …, 2022 - Elsevier
The objective of this study was to investigate the protective effects of Shengmai Yin (SMY)
on rats with chronic heart failure (CHF). Sprague‐Dawley rats were used to establish a CHF …

[HTML][HTML] Metabolomics combined with systematic pharmacology reveals the therapeutic effects of Salvia miltiorrhiza and Radix Pueraria lobata herb pair on type 2 …

W Niu, J Miao, X Li, Q Guo, Z Deng, L Wu - Journal of Functional Foods, 2022 - Elsevier
Abstract Salvia miltiorrhiza and Radix Pueraria lobata herb pair is the core of the
huoxuehuayu method to treat type 2 diabetes in Chinese. However, the mechanisms of this …

Metabolomics study on the periplocin‐induced cardiotoxicity and the compatibility of periplocin and Panax notoginseng saponins in reducing cardiotoxicity in rats by …

W Wang, Y Fan, X Huang, L Li, S Wang… - Journal of …, 2021 - Wiley Online Library
Periplocin, as one of the components of cardiac glycosides in Cortex periplocae, exhibited
cardiotonic effects. Orally ingesting periplocin in high doses or over prolonged periods …

Effect of Qishen granules on isoproterenol‐induced chronic heart failure in rats evaluated by comprehensive metabolomics

S Liu, J Xing, Z Zheng, Z Liu, F Song… - Phytotherapy …, 2022 - Wiley Online Library
Qishen granules (QSG), a Chinese herbal formula, has been widely used in the treatment of
myocardial ischemic chronic heart failure (CHF) for many years, but its mechanism of action …

Establishment of a new arrhythmia model in SD rats induced by isoproterenol

Z Guo, N Zhang, K Ma, Q Lei, G Ma, B Ding… - Acta …, 2023 - Taylor & Francis
Background The main purpose of this study was to establish an ideal arrhythmia model
using isoproterenol and explore its mechanism. Methods Fifty healthy male SD rats were …

Therapeutic effects of different polar fractions of hawthorn extract on blood stasis model rats revealed by liquid chromatography–mass spectrometry metabolomics

L Luo, Q Xue, Y Qi, L Zeng… - Journal of Separation …, 2021 - Wiley Online Library
Hawthorn, a commonly used traditional Chinese medicine, has been suggested to have
therapeutic effects on cardiovascular disease. However, effective fractions of hawthorn …

Establishment of a New Arrhythmia Model in SD Rats Induced by the Isoproterenol" 6+ 1" Mode and Its Mechanisms

ZJ Guo, ZC Wang, KX Ma, B Ding, GP Ma, Y Zhong… - 2021 - researchsquare.com
Background The main purpose is to establish an ideal arrhythmia model with isoproterenol
and explore its mechanism. Methods Fifty healthy male SD rats were randomly divided into …