Diabetic peripheral neuropathy (DPN) is one of the most common chronic complications of
diabetes. Symptoms of DPN mainly include spontaneous intractable pain that is diffuse and …

Secoiridoids are natural products of cyclopentane monoterpene derivatives that are formed
by splitting the rings of cyclomethene oxime compounds at C‐7 and C‐8, and only account …

Rheumatoid arthritis (RA) is among the most prevalent forms of autoimmunity.
Gentiopicroside (Gent) is an iridoid glucoside derived from the Gentiana Macrophylla Pall …

Gentianae Radix et Rhizoma is a medical plant that is widely cultivated in China, North
Korea, Japan, and Russia, and gentiopicroside is one of its major active compounds. In this …

Pulmonary fibrosis (PF) is a chronic and ultimately fatal interstitial lung disease of various
causes. The advent of nintedanib and pirfenidone provides treatment options for PF patients …

Neuropathic pain is a widespread and debilitating chronic pain and the treatment remains a
clinical challenge. Isoorientin (3′, 4′, 5, 7-tetrahydroxy-6-C-glucopyranosyl flavone) is a …

Acute gouty arthritis is a self-limiting inflammatory disease resulting from the deposition of
monosodium urate (MSU) crystals. It has been shown that Gentiopicroside (GPS) possesses …

Osteoporosis is characterized by increased bone fragility, and the drugs used at present to
treat osteoporosis can cause adverse reactions. Gentiopicroside (GEN), a class of natural …

Background/Aims: Gentiopicroside is promising as an important secoiridoid compound
against pain. The present study aimed to investigate the analgesic effect and the probable …

Neuropathic pain is an intractable disease with few definitive therapeutic options. Anethole
(AN) has been confirmed to possess potent anti-inflammatory and neuroprotective …