Cytosine methylation is a common form of post-replicative DNA modification seen in both
bacteria and eukaryotes. Modified cytosines have long been known to act as hotspots …

Cigarette smoke contains numerous chemical compounds, including abundant reactive
oxygen/nitrogen species and aldehydes, and many other carcinogens. Long-term cigarette …

Reporter gene assays, in which a single mutation from each experiment can contribute to
the assembly of a mutation spectrum for an agent, have provided the basis for …

Oxygen derived species such as hydrogen peroxide, superoxide anion radical, hydroxyl
radical (OH-), and singlet oxygen are well known to be cytotoxic and have been implicated …

Simple Summary Nasopharyngeal carcinoma is a serious major public health problem in its
endemic countries. Up to 80% of NPC patients with locally advanced disease or distant …

Aromatic amines are an important group of industrial chemicals, which are widely used for
manufacturing of dyes, pesticides, drugs, pigments, and other industrial products. These …

Genome Sequencing in Cancer Breakthroughs in gene-sequencing methods and
bioinformatics have ushered in a new era in cancer diagnosis and management. Powerful …

Background: Phytochemical compounds are emerging as a new generation of anticancer
agents with limited toxicity in cancer patients. The purpose of this study was to investigate …

Epithelial to mesenchymal transition (EMT) is a process that allows an epithelial cell to
acquire a mesenchymal phenotype through multiple biochemical changes resulting in an …

DNA replication is constantly challenged by DNA lesions, noncanonical DNA structures and
difficult-to-replicate DNA sequences. Two major strategies to rescue a stalled replication fork …