The key characteristics (KC) of human carcinogens provide a uniform approach to
evaluating mechanistic evidence in cancer hazard identification. Refinements to the …

Cellular redox homeostasis is an essential, dynamic process that ensures the balance
between reducing and oxidizing reactions within cells and thus has implications across all …

Tobacco smoke (TS) contains numerous cancer-causing agents, with polycyclic aromatic
hydrocarbons (PAHs) and nitrosamines being most frequently cited as the major TS human …

Lung cancer is the most common form of cancer death worldwide. Although reduction of
tobacco consumption remains the most appropriate strategy to reduce lung-cancer burden …

Large cohort studies in the US and in Europe suggest that air pollution may increase lung
cancer risk. Biomarkers can be useful to understand the mechanisms and to characterize …

Simple Summary Head and neck cancer (HNC) is the sixth most common cancer, causing
almost half a million deaths worldwide every year. The two subtypes of HNC are distinctly …

Mutation is associated with developmental and hereditary disorders, aging, and cancer.
While we understand some mutational processes operative in human disease, most remain …

In recent years several new mouse models for lung cancer have been described. These
include models for both non-small-cell lung cancer (NSCLC) and small-cell lung cancer …

Background Cigarette smoking causes about 30% of all cancer mortality in developed
countries. Although smoking is decreasing in developed countries, it is increasing in some …

To improve the clinical outcome of adoptive NK cell therapy in patients with solid tumors, NK
cells need to persist within the tumor microenvironment (TME) in which the abundance of …