Use of biological therapies for the management of pustular psoriasis: a new era?

M Megna, E Camela, A Ruggiero… - Clinical, cosmetic and …, 2023 - Taylor & Francis
Generalized pustular psoriasis (GPP) is a severe and rare form of psoriasis, being a
potentially life-threatening condition, characterized by recurring episodes or flares of …

Clinical advances in biological therapy for generalized pustular psoriasis: a review

CY Hsieh, TF Tsai - Expert Opinion on Biological Therapy, 2024 - Taylor & Francis
ABSTRACT Introduction In 2022, US Food and Drug Administration (FDA) approved the first
biologics, intravenous spesolimab, for acute flare of generalized pustular psoriasis (GPP) …

Mature IL-36γ Induces Stratum Corneum Exfoliation in Generalized Pustular Psoriasis by Suppressing Corneodesmosin

E Sato, H Imayoshi, Y Tsutsui, H Shimizu… - Journal of Investigative …, 2024 - Elsevier
Loss-of-function sequence variations in the IL36RN gene encoding IL-36 receptor
antagonist cause familial generalized pustular psoriasis, which begins shortly after birth and …

[HTML][HTML] Psoriasis in pediatric age group

S Dhar, SM Srinivas - Indian Journal of Dermatology, 2022 - journals.lww.com
Psoriasis is a common, chronic, immune-mediated, multisystem, inflammatory disorder. It
affects all age groups, including infancy. In one-third of the cases, the onset of the disease is …

Targeting IL-17A for the treatment of pustular psoriasis: a comprehensive review

E Rosi, MT Fastame, A Di Cesare… - Expert Opinion on …, 2022 - Taylor & Francis
Introduction Pustular psoriasis (PP) is a rare subtype of psoriasis. Overall, the growing
evidence–in particular for acute generalized PP (GPP)–supports that it is a separate entity …

The update of treatment strategies in pediatrics with generalized pustular psoriasis in China

Y Chen, X Xiang, Z Wang, C Miao… - Pediatric Investigation, 2023 - Wiley Online Library
Generalized pustular psoriasis (GPP) is a severe subtype of psoriasis, commonly combined
with systemic inflammation. Gene mutations have been found to be associated with GPP …

Successful treatment of a 3‐year‐old girl with generalized pustular psoriasis using secukinumab monotherapy

H Zhu, P Song, D Du, H Tian - Pediatric Dermatology, 2021 - Wiley Online Library
We report a case of a 3‐year‐old girl with generalized pustular psoriasis (GPP) and a
compound heterozygous mutation within the IL36 receptor antagonist (IL36RN) gene at c …

Review of Generalized Pustular Psoriasis: Prevalence, Diagnosis, and Treatment Options

Y Kozina, ACM Musiek… - Journal of Psoriasis and …, 2024 - journals.sagepub.com
Background: Generalized pustular psoriasis (GPP) is a diagnostic challenge for clinicians
and is relatively rare. Prevalence is currently reported to be higher in Asian countries and …

Successful Treatment of SAM Syndrome With Secukinumab Monotherapy: A Case Report of a 16-Month-Old Infant

Q Cao, J Hou, C Pan, L Zhang, D Cheng, X Wang… - Dermatitis®, 2024 - liebertpub.com
Severe dermatitis, multiple allergies, and metabolic wasting (SAM) syndrome is a rare
congenital skin disease. We report on a 16-month-old infant presenting with severe …

Infantile generalized pustular psoriasis with excellent response to secukinumab: a case report

BEK Guevara, JMRM Aquino… - Experimental …, 2023 - pubmed.ncbi.nlm.nih.gov
Infantile generalized pustular psoriasis with excellent response to secukinumab: A case report
Infantile generalized pustular psoriasis with excellent response to secukinumab: A case report …