Currently, enhancement of cholinergic neurotransmission via cholinesterase inhibitors
represents the main available approach to treat cognitive and behavioural symptoms of the …

The superior colliculus (SC) has long been known to be part of the network of brain areas
involved in spatial attention, but recent findings have dramatically refined our understanding …

The synucleinopathy, idiopathic Parkinson's disease, is a multisystem disorder that involves
only a few predisposed nerve cell types in specific regions of the human nervous system …

The present edition of The Human Central Nervous System differs considerably from its
predecessors. In previous editions, the text was essentially confined to a section dealing …

The extent of synchronization within and between the nuclei of the basal ganglia is unknown
in Parkinson's disease. The question is an important one because synchronization will …

Sleep researchers in different disciplines disagree about how fully dreaming can be
explained in terms of brain physiology. Debate has focused on whether REM sleep …

▪ Abstract The organization and possible functions of basal forebrain and pontine cholinergic
systems are reviewed. Whereas the basal forebrain cholinergic neuronal projections likely …

Several theories claim that dreaming is a random by-product of REM sleep physiology and
that it does not serve any natural function. Phenomenal dream content, however, is not as …

Gait disorders and postural instability, which are commonly observed in elderly patients with
Parkinson disease (PD), respond poorly to dopaminergic agents used to treat other …

Akinesia and gait disturbances are particularly incapacitating for patients with Parkinson's
disease. The anatomical and physiological substrates for these disturbances are poorly …