Macrolides are a large group of antibiotics characterised by the presence of a macro-lactone
ring of variable size. The prototype of macrolide antibiotics, erythromycin was first produced …

The tale of abate in antibiotics continued defense mechanisms that chaperone the rise of
drug-defying superbugs—on the other hand, the astray in antibacterial drug discovery and …

In the search for novel hybrid molecules by fusing two biologically active scaffolds into one
heteromeric chemotype, we found that hybrids of azithromycin and ciprofloxacin/gatifloxacin …

Background Resistance to front-line antimalarials (artemisinin combination therapies) is
spreading, and development of new drug treatment strategies to rapidly kill Plasmodium …

Macrolide antibiotics represent a class of natural macrocyclic products, one of the most
clinically important antibiotics. Unfortunately, the production and development of new …

Resistance to telithromycin and off-target effects associated with the metabolic instability
present serious and challenging problems for the development of novel macrolides. Herein …

Staphylococcus aureus (S. aureus), recognized as one of the deadliest pathogens
responsible for nosocomial and community acquired infections, is highly contagious and …

Interleukin 17 (IL-17) cytokines promote inflammatory pathophysiology in many autoimmune
diseases, including psoriasis, multiple sclerosis, rheumatoid arthritis, and inflammatory …

Constitutively erythromycin-resistant apathogens are more difficult to address than inducibly
resistant and efflux-resistant strains. Three series of the 4th generation 2-fluoro 9-oxime …

Background and Purpose Efficacy of current antimalarial treatments is declining as a result
of increasing antimalarial drug resistance, so new and potent antimalarial drugs are urgently …